OMIA:000743-9615 : Optic nerve hypoplasia, bilateral in Canis lupus familiaris (dog) |
Categories: Vision / eye phene
Possibly relevant human trait(s) and/or gene(s) (MIM number): 165550 (trait)
Links to MONDO diseases: No links.
Mendelian trait/disorder: unknown
Considered a defect: yes
Species-specific description: Genetics Committee of the American College of Veterinary Opthalmologists (2021): "a congenital anomaly, which results in a small optic disk diameter and vision loss.Contrast with micropapilla, which may have a similar ophthalmoscopic appearance but without loss of vision."
Genetic engineering:
Unknown
Have human generated variants been created, e.g. through genetic engineering and gene editing
Breeds:
Collie (Dog) (VBO_0200375),
Poodle, Miniature (Dog) (VBO_0201051).
Breeds in which the phene has been documented. For breeds in which a likely causal variant has been documented, see the variant table below
Cite this entry
Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:000743-9615: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70
References
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
| 2021 | Genetics Committee of the American College of Veterinary Opthalmologists : |
| The Blue Book: Ocular disorders presumed to be inherited in purebred dogs. 13th Edition https://ofa.org/wp-content/uploads/2022/10/ACVO-Blue-Book-2021.pdf , 2021. | |
| 2020 | Becker, D., Niggel, J.K., Pearce-Kelling, S., Riis, R.C., Aguirre, G.D. : |
| Optic nerve hypoplasia in miniature poodle dogs: A preliminary genetic and candidate gene association study. Vet Ophthalmol 23:67-76, 2020. Pubmed reference: 31342635. DOI: 10.1111/vop.12691. | |
| 2008 | da Silva, E.G., Dubielzig, R., Zarfoss, M.K., Anibal, A. : |
| Distinctive histopathologic features of canine optic nerve hypoplasia and aplasia: a retrospective review of 13 cases. Vet Ophthalmol 11:23-9, 2008. Pubmed reference: 18190348. DOI: 10.1111/j.1463-5224.2007.00596.x. | |
| 1998 | Termote, S. : |
| What is your diagnosis? Congenital optic nerve hypoplasia in a dog. J Small Anim Pract 39:1, 39, 1998. Pubmed reference: 9494926. | |
| 1981 | Kern, T.J., Riis, R.C. : |
| Optic nerve hypoplasia in three Miniature Poodles. J Am Vet Med Assoc 178:49-54, 1981. Pubmed reference: 7204223. | |
| 1976 | Ernest, J.T. : |
| Bilateral optic nerve hypoplasia in a pup. J Am Vet Med Assoc 168:125-8, 1976. Pubmed reference: 1245453. | |
| 1971 | Gelatt, K.N., Leipold, H.W. : |
| Case report. Bilateral optic nerve hypoplasia in two dogs. Can Vet J 12:91-6, 1971. Pubmed reference: 5104935. | |
| 1952 | Saunders, L.Z. : |
| Congenital optic nerve hypoplasia in Collie dogs Cornell Veterinarian 42:67-80, 1952. Pubmed reference: 14905886. |
Edit History
- Created by Frank Nicholas on 06 Sep 2005
- Changed by Frank Nicholas on 26 Oct 2011
- Changed by Imke Tammen2 on 26 Aug 2021
- Changed by Imke Tammen2 on 20 Oct 2022
- Changed by Imke Tammen2 on 17 Jun 2023