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OMIA:000754-9615 : Osteogenesis imperfecta, generic in Canis lupus familiaris (dog)

In other species: domestic cat , taurine cattle , sheep

Categories: Skeleton phene (incl. short stature & teeth)

Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 166210 (trait) , 166220 (trait) , 259420 (trait)

Links to MONDO diseases: No links.

Mendelian trait/disorder: yes

Mode of inheritance: Autosomal dominant

Considered a defect: yes

Key variant known: no

Cross-species summary: Abnormally brittle bones that fracture easily.

Species-specific description: See also entries for osteogenesis imperfecta for which likely causal variants have been identified, e.g., "OMIA:002112-9615 Osteogenesis imperfecta, COL1A2-related'; 'OMIA:001483-9615 Osteogenesis imperfecta, SERPINH1-related' and 'OMIA:002126-9615 Osteogenesis imperfecta, type III, COL1A1-related'

Genetic engineering: Unknown
Have human generated variants been created, e.g. through genetic engineering and gene editing

Breeds: English Mastiff (Dog) (VBO_0200492), Finnish Lapphund (Dog) (VBO_0200523), German Shepherd Dog (Dog) (VBO_0200577).
Breeds in which the phene has been documented. For breeds in which a likely causal variant has been documented, see the variant table below

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:000754-9615: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70

References

Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2021 Tse, M.Y., Porter, I.R., Demeter, E., Behling-Kelly, E., Wakshlag, J.J., Miller, A.D. :
Osteogenesis imperfecta in two Finnish Lapphund puppies. Vet Med (Auckl) 12:177-185, 2021. Pubmed reference: 34168973. DOI: 10.2147/VMRR.S308418.
2019 Gold, R., Pool, R.R., Edwards, E.E. :
Osteogenesis and dentinogenesis imperfecta in a four-month-old English mastiff. Veterinary Record Case Reports 7:e000835, 2019. DOI: 10.1136/vetreccr-2019-000835.
2000 Lazar, T., deHaan, J.J., Peck, J.N., Campbell, B.G., Ginn, P.E., Phillips, L., Suero, A., Chase, J. :
Osteogenesis imperfecta in three dogs from a single litter Veterinary & Comparative Orthopaedics & Traumatology 13:23-27, 2000.
1997 Campbell, B.G., Wootton, J.A.M., Krook, L., Demarco, J.A., Minor, R.R. :
Clinical signs and diagnosis of osteogenesis imperfecta in three dogs Journal of the American Veterinary Medical Association 211:183 ff., 1997. Pubmed reference: 9227748.
1991 Konig, F. :
Case report - Osteogenesis imperfecta in a German Shepherd puppy. Kleintierpraxis 36:583, 1991.
1960 Lettow, E., Dammrich, K. :
[Contribution to the clinical picture and pathology of Osteogenesis imperfecta in the young dog.] Beitrag zur Klinik und Pathologie der Osteogenesis imperfecta bei Junghunden. Zentralblatt fur Veterinarmedizin 7:936-966, 1960.
1956 Calkins, E., Kalm, D., Diner, W.C. :
Idiopathic familial osteoporosis in dogs: 'Osteogenesis imperfecta' Annals of the New York Academy of Sciences 64:410-423, 1956.

Edit History


  • Created by Frank Nicholas on 12 Sep 2005
  • Changed by Frank Nicholas on 28 Sep 2011
  • Changed by Frank Nicholas on 12 Dec 2011
  • Changed by Frank Nicholas on 15 Sep 2012
  • Changed by Frank Nicholas on 13 Jul 2017
  • Changed by Frank Nicholas on 18 Sep 2017
  • Changed by Imke Tammen2 on 01 Jul 2021
  • Changed by Imke Tammen2 on 05 Jun 2023