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OMIA:000978-9031 : Talpid-2 in Gallus gallus (chicken)

Categories: Limbs / fins / digit / tail phene

Links to MONDO diseases: No links.

Mendelian trait/disorder: yes

Mode of inheritance: Autosomal recessive

Considered a defect: yes

Key variant known: no

Genetic engineering: Unknown
Have human generated variants been created, e.g. through genetic engineering and gene editing

Clinical features: "Homozygotes (-/-) display extreme preaxial polydactly, exposed viscera, cleft palate, parrot-like beak, and dwarfing with greatly reduced leg and wing proximal bones in addition to the duplication of the distal digit bones" (Robb et al., 2011)

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2011). OMIA:000978-9031: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70

References

Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2016 Schock, E.N., Chang, C.F., Youngworth, I.A., Davey, M.G., Delany, M.E., Brugmann, S.A. :
Utilizing the chicken as an animal model for human craniofacial ciliopathies. Dev Biol 415:326-337, 2016. Pubmed reference: 26597494. DOI: 10.1016/j.ydbio.2015.10.024.
2011 Robb, EA., Gitter, CL., Cheng, HH., Delany, ME. :
Chromosomal mapping and candidate gene discovery of chicken developmental mutants and genome-wide variation analysis of MHC congenics. J Hered 102:141-56, 2011. Pubmed reference: 21273214. DOI: 10.1093/jhered/esq122.
2006 Harris, MP., Hasso, SM., Ferguson, MW., Fallon, JF. :
The development of archosaurian first-generation teeth in a chicken mutant. Curr Biol 16:371-7, 2006. Pubmed reference: 16488870. DOI: 10.1016/j.cub.2005.12.047.
2005 Vargas, AO., Fallon, JF. :
Birds have dinosaur wings: The molecular evidence. J Exp Zoolog B Mol Dev Evol 304:86-90, 2005. Pubmed reference: 15880773. DOI: 10.1002/jez.b.21042.
1999 Caruccio, N.C., Martinez-Lopez, A., Harris, M., Dvorak, L., Bitgood, J., Simandl, B.K., Fallon, J.F. :
Constitutive activation of sonic hedgehog signaling in the chicken mutant talpid(2): Shh-independent outgrowth and polarizing activity. Dev Biol 212:137-49, 1999. Pubmed reference: 10419691. DOI: 10.1006/dbio.1999.9321.
1996 Rodriguez, C., Kos, R., Macias, D., Abbott, U.K., Belmonte, J.C.I. :
Shh, hoxd, BMP-2, and FGF-4 gene expression during development of the polydactylous Talpid(2), Diplopodia(1), and Diplopodia(4) mutant chick limb buds Developmental Genetics 19:26-32, 1996. Pubmed reference: 8792606. DOI: 10.1002/(SICI)1520-6408(1996)19:1<26::AID-DVG3>3.0.CO;2-2.
1992 Coelho, C.N.D., Upholt, W.B., Kosher, R.A. :
Role of the chicken homeobox-containing genes GHox-4.6 and GHox-8 in the specification of positional identities during the development of normal and polydactylous chick limb buds Development 115:629-637, 1992. Pubmed reference: 1358596.
1991 Dvorak, L., Fallon, J.F. :
Talpid2 Mutant Chick Limb Has Anteroposterior Polarity and Altered Patterns of Programmed Cell Death Anatomical Record 231:251-260, 1991. Pubmed reference: 1746725. DOI: 10.1002/ar.1092310213.
1980 Perle, M.A., Newman, S.A. :
Talpid2 mutant of the chicken with perturbed cartilage development has an altered precartilage-specific chromatin protein. Proc Natl Acad Sci U S A 77:4828-30, 1980. Pubmed reference: 6933534.
1974 MacCabe, J.A., Abbott, U.K. :
Polarizing and maintenance activities in 2 polydactylous mutants of fowl: diplopodia-1 and talpid-2 Journal of Embryology and Experimental Morphology 31:735-746, 1974.
1964 Goetinck, P.F., Abbott, U.K. :
Studies on limb morphogenesis. I. Experiments with the polydactylous mutant, talpid2 Journal of Experimental Zoology 155:161-170, 1964. Pubmed reference: 14131452.
1959 Abbott, U.K., Taylor, L.W., Abplanalp, H. :
A second talpid-like mutation in the fowl Poultry Science 38:1185-1262, 1959.

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  • Created by Frank Nicholas on 26 Feb 2011