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OMIA:001041-9823 : Ventricular septal defect in Sus scrofa (pig)

In other species: chicken , turkey , dog , domestic cat , horse , taurine cattle , goat , sheep , rabbit , alpaca

Categories: Cardiovascular system phene

Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 614429 (trait) , 614431 (trait) , 614432 (trait)

Links to MONDO diseases: No links.

Mendelian trait/disorder: unknown

Considered a defect: yes

Cross-species summary: A congenital heart defect characterised by persistent patency (open-ness) of the ventricular septum, permitting flow of blood directly between ventricles, bypassing the pulmonary circulation and resulting in various degrees of cyanosis (blue discolouration of the skin) due to oxygen deficiency. Clinical signs include systolic murmur and a palpable thrill on both sides of the chest, dyspnoea and poor tolerance of exercise.

Genetic engineering: Unknown
Have human generated variants been created, e.g. through genetic engineering and gene editing

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2005). OMIA:001041-9823: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70

References

Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

1996 Motsch, J., Weimann, J., Ehehalt, R., Bottiger, B.W., Jakob, H., Schnabel, P.A., Gebhard, M.M., Martin, E. :
Different effect of inhaled nitric oxide on yucatan micropig with and without congenital ventricular septal defect Journal of Experimental Animal Science 38:28-44, 1996. Pubmed reference: 8870413.
1993 Johnson, T.B., Fyfe, D.A., Thompson, R.P., Kline, C.H., Swindle, M.M., Anderson, R.H. :
Echocardiographic and Anatomic Correlation of Ventricular Septal Defect Morphology in Newborn Yucatan Pigs American Heart Journal 125:1067-1072, 1993. Pubmed reference: 8465729.
1991 Ho, S.Y., Thompson, R.P., Gibbs, S.R., Swindle, M.M., Anderson, R.H. :
Ventricular Septal Defects in a Family of Yucatan Miniature Pigs International Journal of Cardiology 33:419-426, 1991. Pubmed reference: 1761337.
1990 Swindle, M.M., Thompson, R.P., Carabello, B.A., Smith, A.C., Hepburn, B.J.S., Bodison, D.R., Corin, W., Fazel, A., Biederman, W.W.R., Spinale, F.G., Gillette, P.C. :
Heritable Ventricular Septal Defect in Yucatan Miniature Swine Laboratory Animal Science 40:155-161, 1990. Pubmed reference: 2157094.

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  • Created by Frank Nicholas on 06 Sep 2005