OMIA:000122-9031 : Blood group system D in Gallus gallus (chicken) |
In other species: horse , pig , aoudad , goat , mouflon , sheep
Categories: Haematopoietic system phene
Links to MONDO diseases: No links.
Mendelian trait/disorder: yes
Mode of inheritance: Autosomal co-dominant
Considered a defect: no
Key variant known: no
Cross-species summary: Each blood group system consists of a set of blood types, each of which corresponds to a particular antigen (usually a glycoprotein) on the surface of red blood cells. The different types within a system are the result of the action of different alleles at a locus that usually encodes an enzyme that catalyses the creation of the feature of the glycoprotein unique to that type, e.g. the presence of a particular sugar at the end of a short chain of sugars.
Inheritance: Briles et al. (1959) confirmed the existence of four loci (blood group systems), namely A, B, D, and E, with some evidence of tight linkage between A and E.
Mapping: Fulton et al. (2023): "Genome-wide association analyses using a 600 K or a 54 K SNP chip plus DNA from independent samples identified a strong peak on chicken chromosome 1 at 125–131 Mb (GRCg6a). Cell surface expression and the presence of exonic non-synonymous SNP were used to identify the candidate gene. The chicken CD99 gene showed the co-segregation of SNP-defined haplotypes and serologically defined D blood system alleles." The authors report the associations between CD99 haplotypes (based eight SNP: rs74153692; rs314496839; rs312634736; rs316308207; rs10730300; rs735363747; rs13623448, rs735519530) and D system alleles.
Genetic engineering:
Unknown
Have human generated variants been created, e.g. through genetic engineering and gene editing
Associated gene:
| Symbol | Description | Species | Chr | Location | OMIA gene details page | Other Links |
|---|---|---|---|---|---|---|
| CD99 | CD99 molecule | Gallus gallus | 1 | NC_052532.1 (128695078..128671094) | CD99 | Homologene, Ensembl , NCBI gene |
Cite this entry
Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:000122-9031: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70
References
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
| 2023 | Fulton, J.E., Drobik-Czwarno, W., Lund, A.R., Schmidt, C.J., Taylor, R.L. : |
| CD99 and the chicken alloantigen D blood system. Genes (Basel) 14:402, 2023. Pubmed reference: 36833329. DOI: 10.3390/genes14020402. | |
| 2000 | Bitgood, JJ., Briles, RW., Briles, WE. : |
| Further tests for genetic linkages of three morphological traits, three blood groups, and break points of two chromosome translocations on chromosome one in the chicken. Poult Sci 79:293-5, 2000. Pubmed reference: 10735192. | |
| 1991 | Bitgood, J.J., Kendall, R.L., Briles, R.W., Briles, W.E. : |
| Erythrocyte alloantigen loci Ea-D and Ea-I map to chromosome 1 in the chicken. Anim Genet 22:449-54, 1991. Pubmed reference: 1789498. | |
| 1984 | Briles, W.E. : |
| Early chicken blood group investigations. Immunogenetics 20:217-26, 1984. Pubmed reference: 6088392. | |
| 1959 | Briles, C.O., McGibbon, W.H., Irwin, M.R. : |
| Additional Alleles Affecting Red Blood Cell Antigens in the Chicken. Genetics 44:955-65, 1959. Pubmed reference: 17247871. |
Edit History
- Created by Frank Nicholas on 06 Sep 2005
- Changed by Frank Nicholas on 14 Oct 2011
- Changed by Imke Tammen2 on 27 Feb 2023