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OMIA:001345-9615 : Tricuspid valve dysplasia in Canis lupus familiaris (dog)

Categories: Cardiovascular system phene

Links to MONDO diseases: No links.

Mendelian trait/disorder: yes

Mode of inheritance: Autosomal recessive

Considered a defect: yes

Key variant known: no

Species-specific name: Canine tricuspid valve malformation (CTVM)

Inheritance: Ohad et al. (2013) provided evidence for autosomal recessive inheritance in Dogue de Bordeaux dogs in Israel.

Mapping: A CTVM susceptibility locus was located on CFA9 by Andelfinger et al. (2003)

Genetic engineering: Unknown
Have human generated variants been created, e.g. through genetic engineering and gene editing

Breeds: Borzoi (Dog) (VBO_0200197), Dogue de Bordeaux (Dog) (VBO_0200450), Labrador Retriever (Dog) (VBO_0200800).
Breeds in which the phene has been documented. For breeds in which a likely causal variant has been documented, see the variant table below

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:001345-9615: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70

References

Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2023 Aherne, M. :
Cardiac disease and screening in breeding dogs. Vet Clin North Am Small Anim Pract , 2023. Pubmed reference: 37353418. DOI: 10.1016/j.cvsm.2023.05.001.
Sykes, K.T., Wesselowski, S., Saunders, A.B., Tjostheim, S.S., Potter, B.M., Gelzer, A.R.M., Katz, N., Ward, J.L., Karlin, E.T., Markovic, L.E., Magee, A.N., Abbott, J.A., Kadotani, S., Menciotti, G. :
A multicenter, retrospective study of cardiac disease in Borzoi dogs. Front Vet Sci 10:1102494, 2023. Pubmed reference: 36777677. DOI: 10.3389/fvets.2023.1102494.
2020 Brambilla, P.G., Polli, M., Pradelli, D., Papa, M., Rizzi, R., Bagardi, M., Bussadori, C. :
Epidemiological study of congenital heart diseases in dogs: Prevalence, popularity, and volatility throughout twenty years of clinical practice. PLoS One 15:e0230160, 2020. Pubmed reference: 32716943. DOI: 10.1371/journal.pone.0230160.
2013 Ohad, D.G., Avrahami, A., Waner, T., David, L. :
The occurrence and suspected mode of inheritance of congenital subaortic stenosis and tricuspid valve dysplasia in Dogue de Bordeaux dogs. Vet J 197:351-7, 2013. Pubmed reference: 23434219. DOI: 10.1016/j.tvjl.2013.01.012.
2011 Arai, S., Griffiths, LG., Mama, K., Hackett, TB., Monnet, E., Boon, JA., Carter, L., Orton, EC. :
Bioprosthesis valve replacement in dogs with congenital tricuspid valve dysplasia: Technique and outcome. J Vet Cardiol 13:91-9, 2011. Pubmed reference: 21640677. DOI: 10.1016/j.jvc.2010.12.002.
Oliveira, P., Domenech, O., Silva, J., Vannini, S., Bussadori, R., Bussadori, C. :
Retrospective review of congenital heart disease in 976 dogs. J Vet Intern Med 25:477-83, 2011. Pubmed reference: 21418326. DOI: 10.1111/j.1939-1676.2011.0711.x.
2004 Andelfinger, G., Hitte, C., Etter, L., Guyon, R., Bourque, G., Tesler, G., Pevzner, P., Kirkness, E., Galibert, F., Benson, DW. :
Detailed four-way comparative mapping and gene order analysis of the canine ctvm locus reveals evolutionary chromosome rearrangements. Genomics 83:1053-62, 2004. Pubmed reference: 15177558. DOI: 10.1016/j.ygeno.2003.12.009.
2003 Andelfinger, G., Wright, KN., Lee, HS., Siemens, LM., Benson, DW. :
Canine tricuspid valve malformation, a model of human Ebstein anomaly, maps to dog chromosome 9. J Med Genet 40:320-4, 2003. Pubmed reference: 12746392.
Baumgartner, C., Glaus, TM. :
[Congenital cardiac diseases in dogs: a retrospective analysis]. Schweiz Arch Tierheilkd 145:527-33, 535-6, 2003. Pubmed reference: 14639823.
2002 Famula, T.R., Siemens, L.M., Davidson, A.P., Packard, M. :
Evaluation of the genetic basis of tricuspid valve dysplasia in Labrador Retrievers American Journal of Veterinary Research 63:816-820, 2002. Pubmed reference: 12061526.
2000 Hoffmann, G., Amberger, CN., Seiler, G., Lombard, CW. :
[Tricuspid valve dysplasia in fifteen dogs]. Schweiz Arch Tierheilkd 142:268-77, 2000. Pubmed reference: 10850163.
1997 Tidholm, A. :
Retrospective study of congenital heart defects in 151 dogs Journal of Small Animal Practice 38:94-98, 1997. Pubmed reference: 9097239.
1973 Mulvihill, J.J., Priester, W.A. :
Congenital heart disease in dogs: epidemiologic similarities to man. Teratology 7:73-7, 1973. Pubmed reference: 4693746. DOI: 10.1002/tera.1420070111.

Edit History


  • Created by Frank Nicholas on 16 Sep 2005
  • Changed by Frank Nicholas on 22 May 2013
  • Changed by Imke Tammen2 on 23 Oct 2022
  • Changed by Imke Tammen2 on 18 Feb 2023