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OMIA:001487-9615 : Myopia in Canis lupus familiaris (dog)

In other species: Rhesus monkey , domestic guinea pig

Categories: Vision / eye phene

Links to MONDO diseases: No links.

Mendelian trait/disorder: no

Mode of inheritance: Multifactorial

Considered a defect: yes

Key variant known: no

Cross-species summary: The condition in which the individual does not see far distances clearly. [ NCIT : P378 ]; "near-sighted."

Inheritance: In an investigation of the heritability of lenticular myopia in English Springer Spaniels, Kubai et al. (2013) reported "Moderate heritability was present for refractive error with a mean value of 0.29 (95% highest probability density: 0.07 to 0.50)".

Genetic engineering: Unknown
Have human generated variants been created, e.g. through genetic engineering and gene editing

Breeds: English Springer Spaniel (Dog) (VBO_0200497), Labrador Retriever (Dog) (VBO_0200800).
Breeds in which the phene has been documented. For breeds in which a likely causal variant has been documented, see the variant table below

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2013). OMIA:001487-9615: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70

References

Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2023 Francis, J.M., Mowat, F.M., Ludwig, A., Hicks, J.M., Pumphrey, S.A. :
Quantifying refractive error in companion dogs with and without nuclear sclerosis: 229 eyes from 118 dogs. Vet Ophthalmol , 2023. Pubmed reference: 37986551. DOI: 10.1111/vop.13163.
2013 Kubai, M.A., Labelle, A.L., Hamor, R.E., Mutti, D.O., Famula, T.R., Murphy, C.J. :
Heritability of lenticular myopia in English Springer spaniels. Invest Ophthalmol Vis Sci 54:7324-8, 2013. Pubmed reference: 24071952. DOI: 10.1167/iovs.12-10993.
2011 Williams, L.A., Kubai, M.A., Murphy, C.J., Mutti, D.O. :
Ocular components in three breeds of dogs with high prevalence of myopia. Optom Vis Sci 88:269-74, 2011. Pubmed reference: 21169876. DOI: 10.1097/OPX.0b013e3182058ff0.
2008 Black, J., Browning, SR., Collins, AV., Phillips, JR. :
A canine model of inherited myopia: familial aggregation of refractive error in labrador retrievers. Invest Ophthalmol Vis Sci 49:4784-9, 2008. Pubmed reference: 18566472. DOI: 10.1167/iovs.08-1828.
1999 Mutti, DO., Zadnik, K., Murphy, CJ. :
Naturally occurring vitreous chamber-based myopia in the Labrador retriever. Invest Ophthalmol Vis Sci 40:1577-84, 1999. Pubmed reference: 10359340.
1992 Murphy, C.J., Zadnik, K., Mannis, M.J. :
Myopia and refractive error in dogs. Invest Ophthalmol Vis Sci 33:2459-63, 1992. Pubmed reference: 1634344.

Edit History


  • Created by Frank Nicholas on 15 Apr 2010
  • Changed by Frank Nicholas on 29 Sep 2013