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OMIA:001614-9685 : Vitamin D-deficiency rickets, non-type I, non-type II in Felis catus (domestic cat)

Categories: Skeleton phene (incl. short stature & teeth)

Links to MONDO diseases: No links.

Mendelian trait/disorder: unknown

Considered a defect: yes

Species-specific description: This disorder is characterised by low levels of both 25-hydroxy-vitamin-D [25(HO)D] and 1,25-hydroxy-vitamin-D [1,25(HO)D], which thus distinguishes it from type I (normal 25(HO)D, low 1,25(HO)D) and type II (normal 25(HO)D, high 1,25(HO)D).

History: Phillips et al. (2011) described this condition in one kitten in a litter of four fed an identical ration. On the basis of this and other evidence, they suggested that this disorder could be due to an inborn error of metabolism, i.e. an enzyme deficiency due to a mutation in the corresponding gene.

Genetic engineering: Unknown
Have human generated variants been created, e.g. through genetic engineering and gene editing

Breed: Cornish Rex (Cat) (VBO_0100077).
Breeds in which the phene has been documented. For breeds in which a likely causal variant has been documented, see the variant table below

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2011). OMIA:001614-9685: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70

References

Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2021 Clarke, K.E., Hurst, E.A., Mellanby, R.J. :
Vitamin D metabolism and disorders in dogs and cats. J Small Anim Pract 62:935-947, 2021. Pubmed reference: 34323302. DOI: 10.1111/jsap.13401.
2011 Phillips, A.M., Fawcett, A.C., Allan, G.S., Wilkinson, M., Fraser, D.R., Malik, R. :
Vitamin D-dependent non-type 1, non-type 2 rickets in a 3-month-old Cornish Rex kitten. J Feline Med Surg 13:526-31, 2011. Pubmed reference: 21704902. DOI: 10.1016/j.jfms.2011.05.010.

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  • Created by Frank Nicholas on 30 Sep 2011