OMIA:000514-9615 : Hypertriglyceridaemia in Canis lupus familiaris (dog) |
In other species: domestic cat
Categories: Homeostasis / metabolism phene
Possibly relevant human trait(s) and/or gene(s) (MIM number): 145750 (trait)
Links to MONDO diseases: No links.
Mendelian trait/disorder: unknown
Considered a defect: yes
Cross-species summary: Elevated fasting serum triglycerides concentrations are called Hypertriglyceridaemia. Primary Hypertriglyceridaemia is caused by genetic defects that cause abnormal triglyceride metabolism while secondary Hypertriglyceridaemia can be associated with other causes, such as nutrition, drugs, and/or other metabolic syndromes.
History: Thanks to Hamutal Mazrier for noting the previous lack of this entry (8 Jan 2015).
Molecular basis: Xenoulis et al. (2020) "concluded that coding variants in APOC2 are unlikely to be a major cause of idiopathic hypertriglyceridemia in North American Miniature Schnauzers".
Genetic engineering:
Unknown
Have human generated variants been created, e.g. through genetic engineering and gene editing
Breed:
Miniature Schnauzer (Dog) (VBO_0200896).
Breeds in which the phene has been documented. For breeds in which a likely causal variant has been documented, see the variant table below
Cite this entry
Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2020). OMIA:000514-9615: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70
References
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
| 2024 | Tate, N.M., Yamkate, P., Xenoulis, P.G., Steiner, J.M., Behling-Kelly, E.L., Rendahl, A.K., Wu, Y.A., Furrow, E. : |
| Clustering analysis of lipoprotein profiles to identify subtypes of hypertriglyceridemia in Miniature Schnauzers. J Vet Intern Med , 2024. Pubmed reference: 38348783. DOI: 10.1111/jvim.17010. | |
| Tate, N.M., Underwood, M., Thomas-Hollands, A., Minor, K.M., Cullen, J.N., Friedenberg, S.G., Mickelson, J.R., Xenoulis, P.G., Steiner, J.M., Furrow, E. : | |
| Sequence analysis of six candidate genes in Miniature Schnauzers with primary hypertriglyceridemia. Genes (Basel) 15:193, 2024. Pubmed reference: 38397183. DOI: 10.3390/genes15020193. | |
| 2023 | Bunn, T., Langner, K., Foster, S., Hayward, D., Howard, G., Paltrinieri, S., Giordano, A., Rossi, G. : |
| Lipoprotein profiles in Miniature Schnauzer dogs with idiopathic hypertriglyceridemia and hypercortisolism. J Vet Diagn Invest :10406387231217505, 2023. Pubmed reference: 38111301. DOI: 10.1177/10406387231217505. | |
| 2020 | Xenoulis, P.G., Tate, N.M., Bishop, M.A., Steiner, J.M., Suchodolski, J.S., Furrow, E. : |
| Sequence analysis of the coding regions of the apolipoprotein C2 (APOC2) gene in Miniature Schnauzers with idiopathic hypertriglyceridemia. Vet J 265:105559, 2020. Pubmed reference: 33129550. DOI: 10.1016/j.tvjl.2020.105559. | |
| 2016 | Furrow, E., Jaeger, J.Q., Parker, V.J., Hinchcliff, K.W., Johnson, S.E., Murdoch, S.J., de Boer, I.H., Sherding, R.G., Brunzell, J.D. : |
| Proteinuria and lipoprotein lipase activity in Miniature Schnauzer dogs with and without hypertriglyceridemia. Vet J 212:83-9, 2016. Pubmed reference: 27256031. DOI: 10.1016/j.tvjl.2016.04.009. | |
| Furrow, E., Lees, G.E., Brown, C.A., Cianciolo, R.E. : | |
| Glomerular Lesions in Proteinuric Miniature Schnauzer Dogs. Vet Pathol :300985816681412, 2016. Pubmed reference: 28005494. DOI: 10.1177/0300985816681412. | |
| 2011 | Xenoulis, P.G., Levinski, M.D., Suchodolski, J.S., Steiner, J.M. : |
| Association of hypertriglyceridemia with insulin resistance in healthy Miniature Schnauzers. J Am Vet Med Assoc 238:1011-6, 2011. Pubmed reference: 21492044. DOI: 10.2460/javma.238.8.1011. | |
| 2008 | Serisier, S., Gayet, C., Leray, V., Le Bloc'h, J., Ouguerram, K., Magot, T., Nguyen, P. : |
| Hypertriglyceridaemic insulin-resistant obese dog model: effects of high-fat diet depending on age. J Anim Physiol Anim Nutr (Berl) 92:419-25, 2008. Pubmed reference: 18662350. DOI: 10.1111/j.1439-0396.2007.00785.x. | |
| Xenoulis, P.G., Suchodolski, J.S., Levinski, M.D., Steiner, J.M. : | |
| Serum liver enzyme activities in healthy Miniature Schnauzers with and without hypertriglyceridemia. J Am Vet Med Assoc 232:63-7, 2008. Pubmed reference: 18167110. DOI: 10.2460/javma.232.1.63. | |
| 2007 | Xenoulis, P.G., Suchodolski, J.S., Levinski, M.D., Steiner, J.M. : |
| Investigation of hypertriglyceridemia in healthy Miniature Schnauzers. J Vet Intern Med 21:1224-30, 2007. Pubmed reference: 18196730. | |
| 2003 | Bailhache, E., Ouguerram, K., Gayet, C., Krempf, M., Siliart, B., Magot, T., Nguyen, P. : |
| An insulin-resistant hypertriglyceridaemic normotensive obese dog model: assessment of insulin resistance by the euglycaemic hyperinsulinaemic clamp in combination with the stable isotope technique. J Anim Physiol Anim Nutr (Berl) 87:86-95, 2003. Pubmed reference: 14511132. | |
| 1993 | Whitney, M.S., Boon, G.D., Rebar, A.H., Story, J.A., Bottoms, G.D. : |
| Ultracentrifugal and electrophoretic characteristics of the plasma lipoproteins of miniature schnauzer dogs with idiopathic hyperlipoproteinemia. J Vet Intern Med 7:253-60, 1993. Pubmed reference: 8246216. DOI: 10.1111/j.1939-1676.1993.tb01016.x. | |
| 1969 | Baum, D., Schweid, A.I., Porte, D., Bierman, E.L. : |
| Congenital lipoprotein lipase deficiency and hyperlipemia in the young puppy. Proc Soc Exp Biol Med 131:183-5, 1969. Pubmed reference: 5814155. |
Edit History
- Created by Frank Nicholas on 08 Jan 2015
- Changed by Frank Nicholas on 08 Jan 2015
- Changed by Hamutal Mazrier on 29 Jan 2015
- Changed by Hamutal Mazrier on 23 Mar 2017
- Changed by Frank Nicholas on 03 Nov 2020