OMIA:002405-9913 : Stature, PLAG1-related in Bos taurus (taurine cattle) |
In other species: indicine cattle (zebu)
Categories: Growth / size / body region phene
Possibly relevant human trait(s) and/or gene(s) (MIM number): 603026 (gene)
Links to MONDO diseases: No links.
Mendelian trait/disorder: no
Mode of inheritance: Multifactorial
Considered a defect: no
Key variant known: no
Species-specific description: Utsunomiya et al. 2017: "Using haplotype analysis, we found evidence that the bovine PLAG1 mutation (Q) with major effects on body size, weight and reproduction is a >1,000 years old derived allele that increased rapidly in frequency in Northwestern European B. taurus between the 16th and 18th centuries. Towards the 19th and 20th centuries, Q was introgressed into non-European B. taurus and Bos indicus breeds. These data implicate a major role of Q in recent changes in body size in modern cattle, and represent one of the first examples of a genomic sweep in livestock that was driven by selection on a complex trait."
Genetic engineering:
Unknown
Have human generated variants been created, e.g. through genetic engineering and gene editing
Associated gene:
| Symbol | Description | Species | Chr | Location | OMIA gene details page | Other Links |
|---|---|---|---|---|---|---|
| PLAG1 | PLAG1 zinc finger | Bos taurus | 14 | NC_037341.1 (23375679..23323709) | PLAG1 | Homologene, Ensembl , NCBI gene |
Cite this entry
Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2021). OMIA:002405-9913: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70
References
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
| 2024 | D'Occhio, M.J., Campanile, G., Baruselli, P.S., Porto Neto, L.R., Hayes, B.J., Collins, A., Fortes, M.R.S. : |
| Pleomorphic adenoma gene (PLAG1) in reproduction and implication for embryonic survival in cattle: A review. J Anim Sci :skae103, 2024. Pubmed reference: 38586898. DOI: 10.1093/jas/skae103. | |
| 2021 | Caivio-Nasner, S., López-Herrera, A., González-Herrera, L.G., Rincón, J.C. : |
| Frequency of genotypic markers for genetic disorders, colour, polledness, and major genes in Blanco Orejinegro cattle. Trop Anim Health Prod 53:546, 2021. Pubmed reference: 34779908. DOI: 10.1007/s11250-021-02990-y. | |
| 2017 | Utsunomiya, Y.T., Milanesi, M., Utsunomiya, A.T.H., Torrecilha, R.B.P., Kim, E.S., Costa, M.S., Aguiar, T.S., Schroeder, S., do Carmo, A.S., Carvalheiro, R., Neves, H.H.R., Padula, R.C.M., Sussai, T.S., Zavarez, L.B., Cipriano, R.S., Caminhas, M.M.T., Hambrecht, G., Colli, L., Eufemi, E., Ajmone-Marsan, P., Cesana, D., Sannazaro, M., Buora, M., Morgante, M., Liu, G., Bickhart, D., Van Tassell, C.P., Sölkner, J., Sonstegard, T.S., Garcia, J.F. : |
| A PLAG1 mutation contributed to stature recovery in modern cattle. Sci Rep 7:17140, 2017. Pubmed reference: 29215042. DOI: 10.1038/s41598-017-17127-1. | |
| 2013 | Fortes, M.R., Kemper, K., Sasazaki, S., Reverter, A., Pryce, J.E., Barendse, W., Bunch, R., McCulloch, R., Harrison, B., Bolormaa, S., Zhang, Y.D., Hawken, R.J., Goddard, M.E., Lehnert, S.A. : |
| Evidence for pleiotropism and recent selection in the PLAG1 region in Australian Beef cattle. Anim Genet , 2013. Pubmed reference: 23909810. DOI: 10.1111/age.12075. |
Edit History
- Created by Imke Tammen2 on 28 Aug 2021
- Changed by Imke Tammen2 on 28 Aug 2021