OMIA:002538-9541 : Alzheimer disease, APP-related in Macaca fascicularis (crab-eating macaque) |
In other species: white-tufted-ear marmoset , Rhesus monkey , dog , pig
Categories: Nervous system phene
Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 104300 (trait) , 104760 (gene) , 605714 (trait)
Links to MONDO diseases:
Mendelian trait/disorder: yes
Considered a defect: yes
Key variant known: yes
Year key variant first reported: 2020
Species-specific description: This animal model of a human disease has been created via transgenic "blastocysts produced by intracytoplasmic sperm injection (ICSI) . . . [being] vitrified and thawed at high efficiency . . . [resulting in] in live births". The resultant animals are, therefore, genetically-modified organisms (GMO).
Genetic engineering:
Yes - variants have been created artificially, e.g. by genetic engineering or gene editing
Have human generated variants been created, e.g. through genetic engineering and gene editing
Associated gene:
| Symbol | Description | Species | Chr | Location | OMIA gene details page | Other Links |
|---|---|---|---|---|---|---|
| APP | amyloid beta precursor protein | Macaca fascicularis | 3 | NC_052257.1 (142113106..141827436) | APP | Homologene, Ensembl , NCBI gene |
Cite this entry
Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:002538-9541: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70
References
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
| 2021 | Yang, W., Chen, X., Li, S., Li, X.J. : |
| Genetically modified large animal models for investigating neurodegenerative diseases. Cell Biosci 11:218, 2021. Pubmed reference: 34933675. DOI: 10.1186/s13578-021-00729-8. | |
| 2020 | Seita, Y., Morimura, T., Watanabe, N., Iwatani, C., Tsuchiya, H., Nakamura, S., Suzuki, T., Yanagisawa, D., Tsukiyama, T., Nakaya, M., Okamura, E., Muto, M., Ema, M., Nishimura, M., Tooyama, I. : |
| Generation of transgenic cynomolgus monkeys overexpressing the gene for amyloid-β precursor protein. J Alzheimers Dis 75:45-60, 2020. Pubmed reference: 32250299. DOI: 10.3233/JAD-191081. |
Edit History
- Created by Imke Tammen2 on 19 Mar 2022
- Changed by Imke Tammen2 on 18 Dec 2023