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OMIA:001114-9615 : Nephritis, autosomal dominant in Canis lupus familiaris (dog)

Categories: Renal / urinary system phene

Possibly relevant human trait(s) and/or gene(s) (MIM number): 104200 (trait)

Links to MONDO diseases: No links.

Mendelian trait/disorder: yes

Mode of inheritance: Autosomal dominant

Considered a defect: yes

Key variant known: no

Species-specific name: similar to Alport syndrome in humans

Species-specific description: The first report of this disorder in dogs was in Bull Terriers, by Hood et al. (1990). The same disorder in Dalmations was reported by Hood et al. (2002) [FN 13 Jan 2003]. For other types of hereditary nephritis see also: 'OMIA001359-9615 Nephritis, autosomal recessive'; 'OMIA001112-9615 Nephritis, x-linked' ;OMIA000708-9615 Nephritis' and 'OMIA 000413-9615 Glomerulonephritis'.

Genetic engineering: Unknown
Have human generated variants been created, e.g. through genetic engineering and gene editing

Breeds: Bull Terrier (Dog) (VBO_0200255), Dalmatian (Dog) (VBO_0200427).
Breeds in which the phene has been documented. For breeds in which a likely causal variant has been documented, see the variant table below

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:001114-9615: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70

References

Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2009 O'Leary, C.A., He, X., Bolton, J.A., Gobe, G., Duffy, D. :
Haplotype sharing excludes orthologous COL4A3, COL4A4 or MYH9 loci in hereditary nephritis in bull terriers. Anim Genet 40:252-3, 2009. Pubmed reference: 19133935. DOI: 10.1111/j.1365-2052.2008.01829.x.
2005 Wiersma, A.C., Millon, L.V., Hestand, M.S., Van Oost, B.A., Bannasch, D.L. :
Canine COL4A3 and COL4A4: sequencing, mapping and genomic organization. DNA Seq 16:241-51, 2005. Pubmed reference: 16147883. DOI: 10.1080/10425170500136822.
2002 Hood, J.C., Huxtable, C., Naito, I., Smith, C., Sinclair, R., Savige, J. :
A novel model of autosomal dominant Alport syndrome in Dalmatian dogs Nephrology Dialysis Transplantation 17:2094-2098, 2002.
Hood, JC., Dowling, J., Bertram, JF., Young, RJ., Huxtable, C., Robinson, W., Savige, J. :
Correlation of histopathological features and renal impairment in autosomal dominant Alport syndrome in Bull terriers. Nephrol Dial Transplant 17:1897-908, 2002. Pubmed reference: 12401844.
Kashtan, C.E. :
Animal models of Alport syndrome. Nephrol Dial Transplant 17:1359-62, 2002. Pubmed reference: 12147777. DOI: 10.1093/ndt/17.8.1359.
2000 Hood, JC., Savige, J., Seymour, AE., Dowling, J., Martinello, P., Colville, D., Sinclair, R., Naito, I., Jennings, G., Huxtable, C. :
Ultrastructural appearance of renal and other basement membranes in the Bull terrier model of autosomal dominant hereditary nephritis. Am J Kidney Dis 36:378-91, 2000. Pubmed reference: 10922317. DOI: 10.1053/ajkd.2000.8989.
1995 Hood, J.C., Savige, J., Hendtlass, A., Kleppel, M.M., Huxtable, C.R., Robinson, W.F. :
Bull terrier hereditary nephritis: a model for autosomal dominant Alport syndrome. Kidney Int 47:758-65, 1995. Pubmed reference: 7752574. DOI: 10.1038/ki.1995.116.
1994 Hood, JC., Craig, AJ. :
Hereditary nephritis in a miniature bull terrier. Vet Rec 135:138-40, 1994. Pubmed reference: 7975107.
1991 Hood, J.C., Robinson, W.F., Clark, W.T., Sutherland, R.J., James, I., Thomas, M.A.B., Huxtable, C.R. :
Proteinuria as an indicator of early renal disease in bull terriers with hereditary nephritis. Journal of Small Animal Practice 32:241-248, 1991.
1990 Hood, J.C., Robinson, W.F., Huxtable, C.R., Bradley, J.S., Sutherland, R.J., Thomas, M.A. :
Hereditary nephritis in the bull terrier: evidence for inheritance by an autosomal dominant gene. Vet Rec 126:456-9, 1990. Pubmed reference: 2356601.

Edit History


  • Created by Frank Nicholas on 06 Sep 2005
  • Changed by Imke Tammen2 on 03 Jun 2022
  • Changed by Imke Tammen2 on 22 Oct 2022
  • Changed by Imke Tammen2 on 12 Jun 2023