OMIA:000439-9925 : Hair, long in Capra hircus (goat) |
In other species: dog , domestic cat , ass (donkey) , Arabian camel , llama , taurine cattle , sheep , rabbit , golden hamster , domestic guinea pig , domestic yak , alpaca
Categories: Integument (skin) phene
Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 190330 (trait) , 165190 (gene)
Links to MONDO diseases:
Mendelian trait/disorder: yes
Considered a defect: no
Key variant known: yes
Year key variant first reported: 2016
Cross-species summary: Long hair = angora
Species-specific description: This phene includes references to studies involving genetically modified organisms (GMO).
Markers: Li et al. (2022) reported a naturally-occurring 507bp deletion roughly 14kb downstream of FGF5 that may be associated with fleece length in goats.
Molecular basis: Wang et al. (2016) reported that "the disruption of FGF5 [by CRISPR/Cas9] results in increased number of second hair follicles and enhanced fiber length in Cas9-mediated goats, suggesting more cashmere will be produced"
Genetic engineering:
Yes - in addition to the occurrence of natural variants, variants have been created artificially, e.g. by genetic engineering or gene editing
Have human generated variants been created, e.g. through genetic engineering and gene editing
Associated gene:
| Symbol | Description | Species | Chr | Location | OMIA gene details page | Other Links |
|---|---|---|---|---|---|---|
| FGF5 | fibroblast growth factor 5 | Capra hircus | - | no genomic information (-..-) | FGF5 | Homologene, Ensembl , NCBI gene |
Cite this entry
Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:000439-9925: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70
References
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
| 2023 | Song, T., Tan, Y., Cuomu, R., Liu, Y., Ba, G., Suo, L., Wu, Y., Cao, X., Zeng, X. : |
| Polymorphisms and mRNA expression levels of IGF-1, FGF5, and KAP 1.4 in Tibetan cashmere goats. Genes (Basel) 14, 2023. Pubmed reference: 36980983. DOI: 10.3390/genes14030711. | |
| 2022 | Li, Y., Song, S., Zhang, Z., Liu, X., Zhang, Y., E, G., Ma, Y., Jiang, L. : |
| A deletion variant within the FGF5 gene in goats is associated with gene expression levels and cashmere growth. Anim Genet 53:657-664, 2022. Pubmed reference: 35843706. DOI: 10.1111/age.13239. | |
| 2019 | Li, G., Zhou, S., Li, C., Cai, B., Yu, H., Ma, B., Huang, Y., Ding, Y., Liu, Y., Ding, Q., He, C., Zhou, J., Wang, Y., Zhou, G., Li, Y., Yan, Y., Hua, J., Petersen, B., Jiang, Y., Sonstegard, T., Huang, X., Chen, Y., Wang, X. : |
| Base pair editing in goat: nonsense codon introgression into FGF5 results in longer hair. FEBS J , 2019. Pubmed reference: 31276295. DOI: 10.1111/febs.14983. | |
| 2016 | Wang, X., Cai, B., Zhou, J., Zhu, H., Niu, Y., Ma, B., Yu, H., Lei, A., Yan, H., Shen, Q., Shi, L., Zhao, X., Hua, J., Huang, X., Qu, L., Chen, Y. : |
| Disruption of FGF5 in Cashmere goats using CRISPR/Cas9 results in more secondary hair follicles and longer fibers. PLoS One 11:e0164640, 2016. Pubmed reference: 27755602. DOI: 10.1371/journal.pone.0164640. | |
| Wang, X., Cai, B., Zhou, J., Zhu, H., Niu, Y., Ma, B., Yu, H., Lei, A., Yan, H., Shen, Q., Shi, L., Zhao, X., Hua, J., Huang, X., Qu, L., Chen, Y. : | |
| Correction: Disruption of FGF5 in Cashmere goats using CRISPR/Cas9 results in more secondary hair follicles and longer fibers. PLoS One 11:e0167322, 2016. Pubmed reference: 27875586. DOI: 10.1371/journal.pone.0167322. | |
| 2014 | He, X., Yuan, C., Chen, Y. : |
| Isolation, characterization, and expression analysis of FGF5 isoforms in cashmere goat. Small Ruminant Research 116:111-117, 2014. | |
| 1987 | Lauvergne, J.J., Renieri, C., Audiot, A. : |
| Estimating erosion of phenotypic variation in a French goat population Journal of Heredity 78:307-314, 1987. Pubmed reference: 3680926. |
Edit History
- Created by Frank Nicholas on 06 Sep 2005
- Changed by Frank Nicholas on 25 Oct 2016
- Changed by Imke Tammen2 on 27 Aug 2021
- Changed by Frank Nicholas on 23 Aug 2022
- Changed by Imke Tammen2 on 15 Nov 2023
- Changed by Imke Tammen2 on 10 Dec 2023