OMIA:000595-89462 : Leukocyte adhesion deficiency, type I in Bubalus bubalis (water buffalo) |
In other species: dog , domestic cat , taurine cattle , indicine cattle (zebu)
Categories: Immune system phene
Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 116920 (trait) , 600065 (gene)
Links to MONDO diseases:
Mendelian trait/disorder: unknown
Considered a defect: yes
Cross-species summary: Affected animals die because of extreme susceptibility to infections, caused by an inability of white blood cells (leukocytes) to pass from the blood stream into infected tissue. This inability is due to the lack of a membrane glycoprotein called the leukocyte integrin beta-2 subunit or CD18.
Species-specific description: This disorder has not yet been reported in this species. The purpose of this entry is to record the study by Sharma et al. (2009) showing that none of the mutations in ITGB2 that cause the disorder in cattle, are present in the buffalo they sampled.
Genetic engineering:
Unknown
Have human generated variants been created, e.g. through genetic engineering and gene editing
Cite this entry
Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2013). OMIA:000595-89462: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70
References
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
| 2009 | Sharma, D., Kumar, S., Deb, SM., Mitra, A., Niranjan, SK., Naskar, S., Sharma, A. : |
| Identification of novel allelic variants of integrin beta 2 (ITGB2) gene and screening for Bubaline leukocyte adhesion deficiency syndrome in Indian water buffaloes (Bubalus bubalis). Anim Biotechnol 20:156-60, 2009. Pubmed reference: 19544212. DOI: 10.1080/10495390902895883. | |
| 2007 | Patel, RK., Singh, KM., Soni, KJ., Chauhan, JB., Sambasiva Rao, KR. : |
| Low incidence of bovine leukocyte adhesion deficiency (BLAD) carriers in Indian cattle and buffalo breeds. J Appl Genet 48:153-5, 2007. Pubmed reference: 17495349. |
Edit History
- Created by Frank Nicholas on 27 Oct 2009
- Changed by Frank Nicholas on 05 Aug 2013