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OMIA:002277-64176 : Skin colour, orange/red in Podarcis muralis (common wall lizard)

Categories: Pigmentation phene

Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 612716 (trait) , 182125 (gene)

Links to MONDO diseases: No links.

Mendelian trait/disorder: yes

Mode of inheritance: Autosomal recessive

Considered a defect: no

Key variant known: no

Inheritance: Andrade et al. (2019): "in 56 of 57 cases, orange and mosaic individuals were homozygous for one allele (hereafter o) at the SPR locus, whereas yellow and white individuals, with one exception, were either heterozygous (n = 41) or homozygous (n = 16) for the alternative allele (hereafter O): a highly significant association (recessive model, P = 9.3 × 10−29)."

Molecular basis: Andrade et al. (2019): "The signal of association for orange coloration was restricted to a noncoding region immediately upstream of SPR"

Genetic engineering: Unknown
Have human generated variants been created, e.g. through genetic engineering and gene editing

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
SPR Podarcis muralis 9 NC_041320.1 (77997231..77994295) SPR Homologene, Ensembl , NCBI gene

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2020). OMIA:002277-64176: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70

References

Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2023 Amer, A., Spears, S., Vaughn, P.L., Colwell, C., Livingston, E.H., McQueen, W., Schill, A., Reichard, D.G., Gangloff, E.J., Brock, K.M. :
Physiological phenotypes differ among color morphs in introduced common wall lizards (Podarcis muralis). Integr Zool , 2023. Pubmed reference: 37884464. DOI: 10.1111/1749-4877.12775.
2021 Andrade, P., Carneiro, M. :
Pterin-based pigmentation in animals. Biol Lett 17:20210221, 2021. Pubmed reference: 34403644. DOI: 10.1098/rsbl.2021.0221.
2019 Andrade, P., Pinho, C., Pérez I de Lanuza, G., Afonso, S., Brejcha, J., Rubin, C.J., Wallerman, O., Pereira, P., Sabatino, S.J., Bellati, A., Pellitteri-Rosa, D., Bosakova, Z., Bunikis, I., Carretero, M.A., Feiner, N., Marsik, P., Paupério, F., Salvi, D., Soler, L., While, G.M., Uller, T., Font, E., Andersson, L., Carneiro, M. :
Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard. Proc Natl Acad Sci U S A 116:5633-5642, 2019. Pubmed reference: 30819892. DOI: 10.1073/pnas.1820320116.

Edit History


  • Created by Frank Nicholas on 17 Jun 2020
  • Changed by Frank Nicholas on 17 Jun 2020