OMIA:000128-9031 : Blood group system H in Gallus gallus (chicken) |
Categories: Haematopoietic system phene
Single-gene trait/disorder: yes
Disease-related: unknown
Key variant known: yes
Year key variant first reported: 2026
Cross-species summary: Each blood group system consists of a set of blood types, each of which corresponds to a particular antigen (usually a glycoprotein) on the surface of red blood cells. The different types within a system are the result of the action of different alleles at a locus that usually encodes an enzyme that catalyses the creation of the feature of the glycoprotein unique to that type, e.g. the presence of a particular sugar at the end of a short chain of sugars.
Mapping: Fulton et al. (2026) mapped the H blood group in chickens to a 4.20–4.30 Mbp region on chromosome 24 using GWAS.
Molecular basis: Fulton et al. (2026) identified a SNP in the MCAM (CD146) gene had an SNP variation that segregated with serological haplotypes: "Lines known to be segregating for the H system had concordance rates between serological results and SNP haplotype of 95% for both the elite HYL lines and 99% for the NIU samples, indicating that the MCAM (CD146) gene encodes the chicken H blood system."
Associated gene:
| Symbol | Description | Species | Chr | Location | OMIA gene details page | Other Links |
|---|---|---|---|---|---|---|
| MCAM | melanoma cell adhesion molecule | Gallus gallus | 24 | NC_052555.1 (4266882..4274784) | MCAM | Ensembl, NCBI gene |
Variants
By default, variants are sorted chronologically by year of publication, to provide a historical perspective.
Readers can re-sort on any column by clicking on the column header. Click it again to sort in a descending
order. To create a multiple-field sort, hold down Shift while clicking on the second, third etc relevant column
headers.
WARNING! Inclusion of a variant in this table does not automatically mean that it should be used for DNA testing. Anyone contemplating the use of any of these variants for DNA testing should examine critically the relevant evidence (especially in breeds other than the breed in which the variant was first described). If it is decided to proceed, the location and orientation of the variant sequence should be checked very carefully.
Since October 2021, OMIA includes a semiautomated lift-over pipeline to facilitate updates of genomic positions to a recent reference genome position. These changes to genomic positions are not always reflected in the ‘acknowledgements’ or ‘verbal description’ fields in this table.
| OMIA Variant ID | Breed(s) | Variant Phenotype | Gene | Allele | Variant Type | Variant Effect | Source of Genetic Variant | AVCG Pathogenicity Classification* | Reference Sequence | Chr. | g. or m. | c. or n. | p. | Verbal Description | EVA ID | Year Published | PubMed ID(s) | Acknowledgements |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1900 | Blood group H | MCAM | H2 | substitution | missense | Naturally occurring variant | Not currently evaluated | GRCg6a | 24 | NC_006111.5:g.4246215G>A | NM_001004768.1:c.144G>A | NP_001004768.1:p.(V482I) | rs739155076 | 2026 | 42074531 |
* Variant pathogenicity for single-gene diseases as evaluated according to the Animal Variant Classification Guidelines (AVCG) by the Variant Pathogenicity Working Group of the International Society of Animal Genetics (ISAG) Animal Genetic Testing Standardization (AGTS) Standing Committee: P = pathogenic, LP = likely pathogenic, VUS = variant of unknown significance, LB = likely benign, B = benign. For more information (including details on the classification of each variant) see LINKS.
Contact us
If you notice anything missing or in need of change, please contact us at: [email protected].
Cite this entry
Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2026). OMIA:000128-9031: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70
Reference
| 2026 | Fulton, J.E., McCarron, A.M., Wolc, A., Sparling, B.A., Ali, L., Jaeger, C., Taylor, R.L. : |
| MCAM (CD146) gene encodes chicken blood alloantigen system H. Genes (Basel) 17:412, 2026. Pubmed reference: 42074531. DOI: 10.3390/genes17040412. |
Edit History
- Created by Imke Tammen2 on 08 May 2026
- Changed by Imke Tammen2 on 09 May 2026