OMIA:000230-9615 : Corneal dystrophy in Canis lupus familiaris (dog)

In other species: domestic cat , rabbit

Categories: Vision / eye phene

Mendelian trait/disorder: unknown

Considered a defect: yes

Species-specific description: Genetics Committee of the American College of Veterinary Opthalmologists (2021): "non-inflammatory corneal opacity (white to gray) present in one or more of the corneal layers (epithelium, stroma, endothelium). The term dystrophy implies an inherited condition. It is usually bilateral although not necessarily symmetrical and the onset in one eye may precede the other."

Breeds: Beagle (Dog) (VBO_0200131), German Shorthaired Pointer (Dog) (VBO_0200583), German Wirehaired Pointer (Dog) (VBO_0200602).
Breeds in which the phene has been documented. (If a likely causal variant has been documented for the phene, see the variant table breeds in which the variant has been reported).

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:000230-9615: Online Mendelian Inheritance in Animals (OMIA) [dataset].


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2021 Genetics Committee of the American College of Veterinary Opthalmologists :
The Blue Book: Ocular disorders presumed to be inherited in purebred dogs. 13th Edition , 2021.
2020 Schuh, J.C.L., Holve, D.L., Mundwiler, K.E. :
Corneal dystrophy in Dutch Belted rabbits as a possible model of Thiel-Behnke subtype of epithelial-stromal TGFβ-induced corneal dystrophy. Toxicol Pathol 49:555-568, 2020. Pubmed reference: 33287658. DOI: 10.1177/0192623320968092.
2018 Shull, O.R., Reilly, C.M., Davis, L.B., Murphy, C.J., Thomasy, S.M. :
Phenotypic characterization of corneal endothelial dystrophy in German Shorthaired and Wirehaired Pointers using in vivo advanced corneal imaging and histopathology. Cornea 37:88-94, 2018. Pubmed reference: 29077583. DOI: 10.1097/ICO.0000000000001431.
1990 Cooley, P.L., Dice, P.F. :
Corneal dystrophy in the dog and cat. Veterinary Clinics of North America-Small Animal Practice 20:681-692, 1990.
1988 Green, W.R., Crispin, S.M. :
Crystalline corneal dystrophy in the dog. Histochemical and ultrastructural study. Cornea 7:149-61, 1988. Pubmed reference: 3261227. DOI: 10.1097/00003226-198802000-00011.
1982 Spangler, W.L., Waring, G.O., Morrin, L.A. :
Oval lipid corneal opacities in Beagles: V. Ultrastructure. Veterinary Pathology 19:150-159, 1982.
1981 Roth, A.M., Ekins, M.B., Waring, G.O., Gupta, L.M., Rosenblatt, L.S. :
Oval corneal opacities in Beagles. III. Histochemical demonstration of stromal lipids without hyperlipidemia. Invest Ophthalmol Vis Sci 21:95-106, 1981. Pubmed reference: 7251305.

Edit History

  • Created by Frank Nicholas on 06 Sep 2005
  • Changed by Imke Tammen2 on 18 Dec 2020
  • Changed by Imke Tammen2 on 17 Jun 2023