In other species: dog , domestic cat

Categories: Muscle phene

Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 135100 (trait) , 102576 (gene)

Links to MONDO diseases: No links.

Mendelian trait/disorder: yes

Considered a defect: yes

Key variant known: no

Cross-species summary: Casal et al. (2019): "also called progressive ossifying myositis and myositis ossificans"

Species-specific description: Trumpp et al. (2023) assessed if medaka are a suitable model for fibrodysplasia ossificans progressiva (FOP), which in humans is caused by variants in the ACVR1 gene: "FOP-typical elevated SMAD signaling [was observed] when the medaka type I receptors carry the R206H equivalent FOP mutation." (GMO)

Genetic engineering: Yes - variants have been created artificially, e.g. by genetic engineering or gene editing
Have human generated variants been created, e.g. through genetic engineering and gene editing