OMIA:000552-9615 : Immunoglobulin A deficiency in Canis lupus familiaris (dog)

In other species: gray wolf

Categories: Immune system phene

Links to MONDO diseases: No links.

Mendelian trait/disorder: unknown

Considered a defect: yes

Mapping: Olsson et al. (2015): "GWAS performed in four breeds prone to low IgA levels (German shepherd, Golden retriever, Labrador retriever and Shar-Pei) identified 35 genomic loci suggestively associated (p <0.0005) to IgA levels. In German shepherd, three genomic regions (candidate genes include KIRREL3 and SERPINA9) were genome-wide significantly associated (p <0.0002) with IgA levels. A ~20kb long haplotype on CFA28, significantly associated (p = 0.0005) to IgA levels in Shar-Pei, was positioned within the first intron of the gene SLIT1."

Genetic engineering: Unknown
Have human generated variants been created, e.g. through genetic engineering and gene editing

Breeds: Chinese Shar-Pei (Dog) (VBO_0200351), German Shepherd Dog (Dog) (VBO_0200577), Golden Retriever (Dog) (VBO_0200610), Labrador Retriever (Dog) (VBO_0200800).
Breeds in which the phene has been documented. For breeds in which a likely causal variant has been documented, see the variant table below

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2016). OMIA:000552-9615: Online Mendelian Inheritance in Animals (OMIA) [dataset].


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2019 Ellis, J.A. :
Canine IgA and IgA deficiency: Implications for immunization against respiratory pathogens. Can Vet J 60:1305-1311, 2019. Pubmed reference: 31814637.
2015 Olsson, M., Tengvall, K., Frankowiack, M., Kierczak, M., Bergvall, K., Axelsson, E., Tintle, L., Marti, E., Roosje, P., Leeb, T., Hedhammar, Å., Hammarström, L., Lindblad-Toh, K. :
Genome-Wide Analyses Suggest Mechanisms Involving Early B-Cell Development in Canine IgA Deficiency. PLoS One 10:e0133844, 2015. Pubmed reference: 26225558. DOI: 10.1371/journal.pone.0133844.
2014 Olsson, M., Frankowiack, M., Tengvall, K., Roosje, P., Fall, T., Ivansson, E., Bergvall, K., Hansson-Hamlin, H., Sundberg, K., Hedhammar, A., Lindblad-Toh, K., Hammarström, L. :
The dog as a genetic model for immunoglobulin A (IgA) deficiency: identification of several breeds with low serum IgA concentrations. Vet Immunol Immunopathol 160:255-9, 2014. Pubmed reference: 24935667. DOI: 10.1016/j.vetimm.2014.05.010.
2013 Frankowiack, M., Hellman, L., Zhao, Y., Arnemo, J.M., Lin, M., Tengvall, K., Møller, T., Lindblad-Toh, K., Hammarström, L. :
IgA deficiency in wolves. Dev Comp Immunol 40:180-4, 2013. Pubmed reference: 23352622. DOI: 10.1016/j.dci.2013.01.005.
2003 Norris, C.R., Gershwin, L.J. :
Evaluation of systemic and secretory IgA concentrations and immunohistochemical stains for IgA-containing B cells in mucosal tissues of an Irish setter with selective IgA deficiency Journal of the American Animal Hospital Association 39:247-50, 2003. Pubmed reference: 12755197.
1996 Tipold, A., Pfister, H., Jungi, T.W. :
IgA-deficiency in the dog [German] Praktische Tierarzt 77:181 ff., 1996.
1992 Mansfield, L.S., Schad, G.A. :
Strongyloides-stercoralis Infection in IgA-Deficient Dogs American Journal of Tropical Medicine and Hygiene 47:830-836, 1992. Pubmed reference: 1471742.
1991 Campbell, K.L., Neitzel, C., Zuckermann, F.A. :
Immunoglobulin-A Deficiency in the Dog Canine Practice 16:7-11, 1991.

Edit History

  • Created by Frank Nicholas on 06 Sep 2005
  • Changed by Frank Nicholas on 27 May 2016