OMIA:000595-9915 : Leukocyte adhesion deficiency, type I in Bos indicus (indicine cattle (zebu))

In other species: dog , domestic cat , taurine cattle , water buffalo

Categories: Immune system phene

Links to possible relevant human trait(s) and/or gene(s) in OMIM: 116920 (trait) , 600065 (gene)

Links to relevant human diseases in MONDO:

Mendelian trait/disorder: unknown

Considered a defect: yes

Cross-species summary: Affected animals die because of extreme susceptibility to infections, caused by an inability of white blood cells (leukocytes) to pass from the blood stream into infected tissue. This inability is due to the lack of a membrane glycoprotein called the leukocyte integrin beta-2 subunit or CD18.

Species-specific description: Sudhakar et al. (2023) investigated introgression of lethal alleles from taurine cattle into Bos taurus × Bos indicus and Bos indicus cattle in India: “Breed purity analysis confirmed inheritance of Bos taurus genes contributing to the presence of lethal mutant alleles like BLAD, Citrullinemia, HH1, and JH1 in apparently phenotypic Bos indicus animals.”

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:000595-9915: Online Mendelian Inheritance in Animals (OMIA) [dataset].


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2023 Sudhakar, A., Nayee, N., Saha, S., Donthula, S.K., Poojara, H.V., Gohil, T., Patel, A.C., Maurya, B.K. :
Role of genetic introgression in introducing mutant alleles in Bos indicus cattle and prevalence of lethal genetic disorders in Bos taurus × Bos indicus and Bos indicus cattle in India. Trop Anim Health Prod 55:399, 2023. Pubmed reference: 37940810. DOI: 10.1007/s11250-023-03798-8.
2012 Nasreen, F., Malik, N.A., Qureshi, J.A., Raadsma, H.W., Tammen, I. :
Identification of a null allele in genetic tests for bovine leukocyte adhesion deficiency in Pakistani Bos indicus × Bos taurus cattle. Mol Cell Probes 26:259-62, 2012. Pubmed reference: 22374219. DOI: 10.1016/j.mcp.2012.01.004.

Edit History

  • Created by Imke Tammen2 on 21 Nov 2023
  • Changed by Imke Tammen2 on 21 Nov 2023