OMIA:000649-8128 : Microphthalmia in Oreochromis niloticus (Nile tilapia)

In other species: chicken , dog , pig , Eastern wapiti , taurine cattle , sheep , golden hamster , fox squirrel , Campbell's desert hamster , water buffalo

Categories: Vision / eye phene

Mendelian trait/disorder: yes

Considered a defect: yes

Key variant known: no

Cross-species summary: Abnormal smallness in all dimensions of one or both eyes.

Inheritance: CRISPR/Cas9 gene editing was used to create mutations (GMO).

Clinical features: Hyperpigmentation body phenotype and microphthalmia

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
GATA2A Oreochromis niloticus LG5 NC_031970.2 (30193896..30180310) GATA2A Homologene, Ensembl , NCBI gene

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2021). OMIA:000649-8128: Online Mendelian Inheritance in Animals (OMIA) [dataset].


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2023 Liu, X., Zhou, L., Li, W., Wu, J., Wang, D. :
Gata2a mutation causes progressive microphthalmia and blindness in Nile tilapia. Int J Mol Sci 24:3567, 2023. Pubmed reference: 36834978. DOI: 10.3390/ijms24043567.
2021 Wang, C., Lu, B., Li, T., Liang, G., Xu, M., Liu, X., Tao, W., Zhou, L., Kocher, T.D., Wang, D. :
Nile tilapia: A model for studying teleost color patterns. J Hered 112:469-484, 2021. Pubmed reference: 34027978. DOI: 10.1093/jhered/esab018.

Edit History

  • Created by Imke Tammen2 on 26 May 2021
  • Changed by Imke Tammen2 on 26 May 2021