OMIA:000684-9615 : Myasthenia in Canis lupus familiaris (dog)

In other species: domestic cat , taurine cattle , Amur tiger

Categories: Nervous system phene

Links to possible relevant human trait(s) and/or gene(s) in OMIM: 254200 (trait) , 254210 (trait)

Single-gene trait/disorder: yes

Disease-related: yes

Key variant known: no

Cross-species summary: Myasthenia is a syndrome of impaired neuromuscular transmission. The syndrome can occur as an acquired autoimmune disorder (myasthenia gravis) or as a congenital genetic disorder (see also separate gene-specific myasthenic syndrome entries). Phene was renamed from 'Myasthenia gravis' to 'Myasthenia' [14/10/2022]

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Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2005). OMIA:000684-9615: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70

References

Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2025 Dos Santos, R.X., Waelkens, J., Crawford, A.H., Khan, S., Sami, S., Gomes, S.A., Van Ham, A., Van Soens, I., Cornelis, I., Canning, J., Fenn, J., Waters, P., Bhatti, S.F.M., Vanhaesebrouck, A.E. :
Case series of canine myasthenia gravis: A classification approach with consideration of seronegative dogs. J Vet Intern Med 39:e70113, 2025. Pubmed reference: 40298067. DOI: 10.1111/jvim.70113.
Reyes, H.M., Galli, G., Fiorentino, E., Gardini, A., Bravaccini, B., Menchetti, M. :
Case Report: Dropped head syndrome as a main clinical sign of suspected myasthenia gravis in two dogs. Front Vet Sci 12:1652576, 2025. Pubmed reference: 41078500. DOI: 10.3389/fvets.2025.1652576.
2020 Mignan, T., Targett, M., Lowrie, M. :
Classification of myasthenia gravis and congenital myasthenic syndromes in dogs and cats. J Vet Intern Med 34:1707-1717, 2020. Pubmed reference: 32668077. DOI: 10.1111/jvim.15855.
2016 Shelton, G.D. :
Myasthenia gravis and congenital myasthenic syndromes in dogs and cats: A history and mini-review. Neuromuscul Disord 26:331-4, 2016. Pubmed reference: 27080328. DOI: 10.1016/j.nmd.2016.03.002.
2011 Khorzad, R., Whelan, M., Sisson, A., Shelton, GD. :
Myasthenia gravis in dogs with an emphasis on treatment and critical care management. J Vet Emerg Crit Care (San Antonio) 21:193-208, 2011. Pubmed reference: 21631705. DOI: 10.1111/j.1476-4431.2011.00636.x.
2005 Dickinson, PJ., Sturges, BK., Shelton, GD., LeCouteur, RA. :
Congenital myasthenia gravis in Smooth-Haired Miniature Dachshund dogs. J Vet Intern Med 19:920-3, 2005. Pubmed reference: 16355692.
2002 Shelton, G.D. :
Myasthenia gravis and disorders of neuromuscular transmission Veterinary Clinics of North America - Small Animal Practice 32:189-+, 2002.
2001 Shelton, G.D., Skeie, G.O., Kass, P.H., Aarli, J.A. :
Titin and ryanodine receptor autoantibodies in dogs with thymoma and late-onset myasthenia gravis Veterinary Immunology & Immunopathology 78:97-105, 2001.
2000 Ridyard, A.E., Rhind, S.M., French, A.T., Munro, E.A.C., Hill, P.B. :
Myasthenia gravis associated with cutaneous lymphoma in a dog Journal of Small Animal Practice 41:348-351, 2000. Pubmed reference: 11002936.
1999 Dewey, C.W., Coates, J.R., Ducote, J.M., Meeks, J.C., Fradkin, J.M. :
Azathioprine therapy for acquired myasthenia gravis in five dogs Journal of the American Animal Hospital Association 35:396-402, 1999. Pubmed reference: 10493415.
Lipsitz, D., Berry, J.L., Shelton, G.D. :
Inherited predisposition to myasthenia gravis in Newfoundlands Journal of the American Veterinary Medical Association 215:956-+, 1999. Pubmed reference: 10511859.
Shelton, G.D. :
Acquired myasthenia gravis: what we have learned from experimental and spontaneous animal models Veterinary Immunology & Immunopathology 69:239-249, 1999.
Yoshioka, T., Uzuka, Y., Tanabe, S., Saraskina, T., Ishiguro, N. :
Molecular cloning of the canine nicotinic acetylcholine receptor alpha-subunit gene and development of the ELISA method to diagnose myasthenia gravis Veterinary Immunology & Immunopathology 72:315-324, 1999.
1998 King, L.G., Vite, C.H. :
Acute fulminating myasthenia gravis in five dogs Journal of the American Veterinary Medical Association 212:830 ff., 1998.
Shelton, G.D. :
Myasthenia gravis - lessons from the past 10 years Journal of Small Animal Practice 39:368-372, 1998. Pubmed reference: 9741871.
1997 Dewey, C.W. :
Acquired myasthenia gravis in dogs .1 Compendium on Continuing Education for the Practicing Veterinarian 19:1340 ff., 1997.
Dewey, C.W., Bailey, C.S., Shelton, G.D., Kass, P.H., Cardinet, G.H. :
Clinical forms of acquired myasthenia gravis in dogs - 25 cases (1988-1995) Journal of Veterinary Internal Medicine 11:50-57, 1997. Pubmed reference: 9127290.
Shelton, G.D., Schule, A., Kass, P.H. :
Risk factors for acquired myasthenia gravis in dogs - 1,154 cases (1991-1995) Journal of the American Veterinary Medical Association 211:1428 ff., 1997.
Webb, A.A., Taylor, S.M., Mcphee, L. :
Focal myasthenia gravis in a dog Canadian Veterinary Journal - Revue Veterinaire Canadienne 38:493-495, 1997.
1996 Lainesse, M.F.C., Taylor, S.M., Myers, S.L., Haines, D., Fowler, J.D. :
Focal myasthenia gravis as a paraneoplastic syndrome of canine thymoma - improvement following thymectomy Journal of the American Animal Hospital Association 32:111-117, 1996. Pubmed reference: 8680916.
1995 Dewey, C.W., Shelton, G.D., Bailey, C.S., Willard, M.D., Podell, M., Collins, R.L. :
Neuromuscular dysfunction in five dogs with acquired myasthenia gravis and presumptive hypothyroidism Progress in Veterinary Neurology 6:117-123, 1995.
Hackett, T.B., Vanpelt, D.R., Willard, M.D., Martin, L.G., Shelton, G.D., Wingfield, W.E. :
Third degree atrioventricular block and acquired myasthenia gravis in four dogs Journal of the American Veterinary Medical Association 206:1173-1176, 1995. Pubmed reference: 7768738.
1994 Kohn, B., Waxenberger, M. :
Myasthenia Gravis in the Dog Praktische Tierarzt 75:118-120, 1994.
Vanham, L.M.L. :
A Myasthenic-Like Syndrome in Young Related Mongrel Dogs Vlaams Diergeneeskundig Tijdschrift 63:146-149, 1994.
1992 Hopkins, A.L. :
Canine Myasthenia Gravis Journal of Small Animal Practice 33:477-484, 1992.
1990 Beddow, B. :
Myasthenia Gravis in a Dog Veterinary Record 127:244, 1990. Pubmed reference: 2260272.
Moore, A.S., Madewell, B.R., Cardinet, G.H., Shelton, G.D. :
Osteogenic Sarcoma and Myasthenia Gravis in a Dog Journal of the American Veterinary Medical Association 197:226-227, 1990. Pubmed reference: 2384323.
Shelton, G.D., Fujii, Y., Lindstrom, J. :
Mitogen Stimulation of Canine Normal and Myasthenia Gravis Lymphocytes Veterinary Immunology and Immunopathology 24:1-9, 1990. Pubmed reference: 2316185.
1976 Jenkins, W.L., Dyk, E. van, McDonald, C.B. :
Myasthenia gravis in a Fox Terrier litter Journal of the South African Veterinary Association 47:59-62, 1976. Pubmed reference: 1263198.
1974 Palmer, A.C., Barker, J. :
Myasthenia in the dog. Vet Rec 95:452-4, 1974. Pubmed reference: 4446286. DOI: 10.1136/vr.95.20.452.

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  • Created by Frank Nicholas on 06 Sep 2005