OMIA:000968-9615 : Systemic lupus erythematosus in Canis lupus familiaris (dog)

In other species: domestic cat

Categories: Immune system phene

Possibly relevant human trait(s) and/or gene(s) (MIM number): 152700 (trait)

Links to MONDO diseases: No links.

Mendelian trait/disorder: no

Mode of inheritance: Multifactorial

Considered a defect: yes

Key variant known: no

Mapping: Working within the LUPA consortium, Wilbe et al. (2010) conducted a GWAS on 81 affected and 57 control Nova Scotia Duck-Tolling Retrievers, each genotyped with the CanineSNP20 BeadChip (comprising 22,000 SNPs). They identified five loci (on chromosomes CFA 3, 8, 11, 24 and 32) that each increase the risk of SLE around five-fold.

Genetic engineering: Unknown
Have human generated variants been created, e.g. through genetic engineering and gene editing

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2021). OMIA:000968-9615: Online Mendelian Inheritance in Animals (OMIA) [dataset].


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2023 Bizikova, P., Olivry, T., Linder, K., Rybnicek, J. :
Spontaneous autoimmune subepidermal blistering diseases in animals: a comprehensive review. BMC Vet Res 19:55, 2023. Pubmed reference: 36849885. DOI: 10.1186/s12917-023-03597-1.
Wyatt, E.K., Schmidt, V., Legnani, S. :
Canine cutaneous lupus erythematosus with prominent interdigital lesions in two greyhounds. Vet Dermatol , 2023. Pubmed reference: 38044797. DOI: 10.1111/vde.13220.
2020 Levy, B.J., Linder, K.E., Mamo, L.B., Herrmann, I., Bizikova, P. :
Cutaneous polyautoimmunity in two unrelated dogs: pemphigus foliaceus and generalized discoid lupus erythematosus. Vet Dermatol 31:325-e84, 2020. Pubmed reference: 32342582. DOI: 10.1111/vde.12851.
2016 Banovic, F., Linder, K.E., Uri, M., Rossi, M.A., Olivry, T. :
Clinical and microscopic features of generalized discoid lupus erythematosus in dogs (10 cases). Vet Dermatol , 2016. Pubmed reference: 27747960. DOI: 10.1111/vde.12389.
2015 Wilbe, M., Kozyrev, S.V., Farias, F.H., Bremer, H.D., Hedlund, A., Pielberg, G.R., Seppälä, E.H., Gustafson, U., Lohi, H., Carlborg, Ö., Andersson, G., Hansson-Hamlin, H., Lindblad-Toh, K. :
Multiple changes of gene expression and function reveal genomic and phenotypic complexity in SLE-like disease. PLoS Genet 11:e1005248, 2015. Pubmed reference: 26057447. DOI: 10.1371/journal.pgen.1005248.
2013 Olivry, T., Linder, K.E. :
Bilaterally symmetrical alopecia with reticulated hyperpigmentation: a manifestation of cutaneous lupus erythematosus in a dog with systemic lupus erythematosus. Vet Pathol 50:682-5, 2013. Pubmed reference: 23051917. DOI: 10.1177/0300985812463406.
2010 Wilbe, M., Jokinen, P., Truve, K., Seppala, EH., Karlsson, EK., Biagi, T., Hughes, A., Bannasch, D., Andersson, G., Hansson-Hamlin, H., Lohi, H., Lindblad-Toh, K. :
Genome-wide association mapping identifies multiple loci for a canine SLE-related disease complex. Nat Genet 42:250-4, 2010. Pubmed reference: 20101241. DOI: 10.1038/ng.525.
2009 Wilbe, M., Jokinen, P., Hermanrud, C., Kennedy, LJ., Strandberg, E., Hansson-Hamlin, H., Lohi, H., Andersson, G. :
MHC class II polymorphism is associated with a canine SLE-related disease complex. Immunogenetics 61:557-64, 2009. Pubmed reference: 19636550. DOI: 10.1007/s00251-009-0387-6.
2002 Soulard, M., Della, Valle, V., Larsen, C.J. :
Autoimmune antibodies to hnRNPG protein in dogs with systemic lupus erythematosus: Epitope mapping of the antigen Journal of Autoimmunity 18:221-229, 2002. Pubmed reference: 12126635.
1999 Chabanne, L., Fournel, C., Rigal, D., Monier, J.C. :
Canine systemic lupus erythematosus. Part II. Diagnosis and treatment Compendium on Continuing Education for the Practicing Veterinarian 21:402-+, 1999.
Chabanne, L., Fournel, C., Monestier, M., Monier, J.C., Rigal, D. :
Canine systemic lupus erythematosus. Part I. Clinical and biologic aspects Compendium on Continuing Education for the Practicing Veterinarian 21:135-141, 1999.
Clercx, C., McEntee, K., Gilbert, S., Michiels, L., Snaps, F., Jacquinet, E., Desmecht, D., Henroteaux, M., Bernadina, W.E. :
Nonresponsive generalized bacterial infection associated with systemic lupus erythematosus in a Beauceron Journal of the American Animal Hospital Association 35:220-+, 1999. Pubmed reference: 10333260.
Olivry, T., Savary, K.C.M., Murphy, K.M., Dunston, S.M., Chen, M. :
Bullous systemic lupus erythematosus (type I) in a dog Veterinary Record 145:165-169, 1999. Pubmed reference: 10466774.
1996 Felchle, L.M., Mcphee, L.A., Kerr, M.E., Houston, D.M. :
Systemic lupus erythematosus and bone marrow necrosis in a dog Canadian Veterinary Journal - Revue Veterinaire Canadienne 37:742-744, 1996.
1995 Bell, S.C., Carter, S.D., May, C., Bennett, D. :
Antibodies to heat shock proteins in dogs with rheumatoid arthritis and systemic lupus erythematosus British Veterinary Journal 151:271-279, 1995. Pubmed reference: 7640956.
Chabanne, L., Fournel, C., Caux, C., Bernaud, J., Bonnefond, C., Monier, J.C., Rigal, D. :
Abnormalities of lymphocyte subsets in canine systemic lupus erythematosus Autoimmunity 22:1-8, 1995. Pubmed reference: 8882416.
Monestier, M., Novick, K.E., Karam, E.T., Chabanne, L., Monier, J.C., Rigal, D. :
Autoantibodies to histone, DNA and nucleosome antigens in canine systemic lupus erythematosus Clinical and Experimental Immunology 99:37-41, 1995. Pubmed reference: 7529150.
1993 Bell, S.C., Carter, S.D., May, C., Bennett, D. :
IgA and IgM Rheumatoid Factors in Canine Rheumatoid Arthritis Journal of Small Animal Practice 34:259-264, 1993.
Goudswaard, J., Schell, W.E.R., Vantoor, A.J., Crama, K. :
SLE (Systemic Lupus Erythematosus) - Related Clinical Features in the Dog Tijdschrift Voor Diergeneeskunde 118:185-189, 1993. Pubmed reference: 8465348.
Jones, D.R.E. :
Canine Systemic Lupus Erythematosus - New Insights and Their Implications - Review Article Journal of Comparative Pathology 108:215-228, 1993. Pubmed reference: 8315051.

Edit History

  • Created by Frank Nicholas on 21 Jul 2011
  • Changed by Frank Nicholas on 21 May 2013
  • Changed by Imke Tammen2 on 10 Sep 2021