OMIA:001302-9031 : Resistance/susceptibility to avian sarcoma and leukosis viruses, subgroup B in Gallus gallus (chicken) |
Categories: Immune system phene
Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 603612 (gene) , 275355 (trait)
Links to MONDO diseases: No links.
Mendelian trait/disorder: yes
Mode of inheritance: Autosomal recessive
Considered a defect: yes
Key variant known: yes
Year key variant first reported: 2002
Species-specific name: tvb locus
Species-specific symbol: tvb
Species-specific description: As in many other cases of single-locus resistance, resistance to type B avian leukosis viruses is due to the lack of a functional receptor for the viruses.
Inheritance: Resistance to the B subgroup of avian sarcoma and leukosis viruses is a single-locus trait, with susceptibility being dominant and resistance recessive (Crittenden et al. 1967), who named the locus "tumour virus b" (tvb).
Molecular basis: By cloning and sequencing a very likely candidate gene (based on knowledge of the receptor that results in susceptibility), Klucking et al. (2002) reported that the tvb gene "is a tumor necrosis factor receptor (TNFR)-related death receptor that is most similar to the mammalian TNF-related apoptosis-inducing ligand (TRAIL) receptors DR4 and DR5". They also showed that resistance is due to a nonsense mutation (C172T) that results in a "severely truncated protein product". The TVB gene is now known as TNFRSF10B.
Genetic engineering:
Unknown
Have human generated variants been created, e.g. through genetic engineering and gene editing
Associated gene:
| Symbol | Description | Species | Chr | Location | OMIA gene details page | Other Links |
|---|---|---|---|---|---|---|
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | Gallus gallus | 22 | NC_052553.1 (1325172..1331767) | TNFRSF10B | Homologene, Ensembl , NCBI gene |
Variants
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WARNING! Inclusion of a variant in this table does not automatically mean that it should be used for DNA testing. Anyone contemplating the use of any of these variants for DNA testing should examine critically the relevant evidence (especially in breeds other than the breed in which the variant was first described). If it is decided to proceed, the location and orientation of the variant sequence should be checked very carefully.
Since October 2021, OMIA includes a semiautomated lift-over pipeline to facilitate updates of genomic positions to a recent reference genome position. These changes to genomic positions are not always reflected in the ‘acknowledgements’ or ‘verbal description’ fields in this table.
| OMIA Variant ID | Breed(s) | Variant Phenotype | Gene | Allele | Type of Variant | Source of Genetic Variant | Reference Sequence | Chr. | g. or m. | c. or n. | p. | Verbal Description | EVA ID | Inferred EVA rsID | Year Published | PubMed ID(s) | Acknowledgements |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 13 | Resistance to avian sarcoma and leukosis viruses, subgroup B | TNFRSF10B | missense | Naturally occurring variant | 22 | c.G>C | p.(C125S) | 2008 | 18094190 | ||||||||
| 324 | Resistance to avian sarcoma and leukosis viruses, subgroup B | TNFRSF10B | nonsense (stop-gain) | Naturally occurring variant | GRCg6a | 22 | g.1418711C>T | c.172C>T | p.(Q58*) | rs736008824 | rs736008824 | 2002 | 12097608 | Variant coordinates obtained from or confirmed by EBI's Some Effect Predictor (VEP) tool |
Cite this entry
Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:001302-9031: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70
References
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
| 2011 | Yang, J., Yu, Y., Yao, J., Chen, Y., Xu, G., Yang, N., Sun, D., Zhang, Y. : |
| Molecular identification of avian leukosis virus subgroup E loci and tumor virus B locus in Chinese indigenous chickens. Poult Sci 90:759-65, 2011. Pubmed reference: 21406360. DOI: 10.3382/ps.2010-01133. | |
| 2009 | Asimakopoulos, F., Varmus, H.E. : |
| Cell-specific transduction of Prdm1-expressing lineages mediated by a receptor for avian leukosis virus subgroup B. J Virol 83:4835-43, 2009. Pubmed reference: 19279099. DOI: 10.1128/JVI.02254-08. | |
| 2008 | Hunt, H., Fadly, A., Silva, R., Zhang, H. : |
| Survey of endogenous virus and TVB* receptor status of commercial chicken stocks supplying specific-pathogen-free eggs. Avian Dis 52:433-40, 2008. Pubmed reference: 18939631. | |
| Reinisová, M., Senigl, F., Yin, X., Plachy, J., Geryk, J., Elleder, D., Svoboda, J., Federspiel, M.J., Hejnar, J. : | |
| A single-amino-acid substitution in the TvbS1 receptor results in decreased susceptibility to infection by avian sarcoma and leukosis virus subgroups B and D and resistance to infection by subgroup E in vitro and in vivo. J Virol 82:2097-105, 2008. Pubmed reference: 18094190. DOI: 10.1128/JVI.02206-07. | |
| Yu, Y., Zhang, H., Tian, F., Bacon, L., Zhang, Y., Zhang, W., Song, J. : | |
| Quantitative evaluation of DNA methylation patterns for ALVE and TVB genes in a neoplastic disease susceptible and resistant chicken model. PLoS One 3:e1731, 2008. Pubmed reference: 18320050. DOI: 10.1371/journal.pone.0001731. | |
| 2007 | Zhang, H.M., Bacon, L.D., Heidari, M., Muir, W.M., Groenen, M.A., Zhang, Y., Wong, G.K., Fulton, J.E., O'Sullivan, N.P., Albers, G.A., Vereijken, A.L., Rattink, A.P., Okimoto, R., McKay, J.C., McLeod, S., Cheng, H.H. : |
| Genetic variation at the tumour virus B locus in commercial and laboratory chicken populations assessed by a medium-throughput or a high-throughput assay. Avian Pathol 36:283-91, 2007. Pubmed reference: 17620174. DOI: 10.1080/03079450701449248. | |
| 2005 | Zhang, H.M., Bacon, L.D., Cheng, H.H., Hunt, H.D. : |
| Development and validation of a PCR-RFLP assay to evaluate TVB haplotypes coding receptors for subgroup B and subgroup E avian leukosis viruses in White Leghorns. Avian Pathol 34:324-31, 2005. Pubmed reference: 16147569. DOI: 10.1080/03079450500179491. | |
| 2004 | Klucking, S., Young, J.A. : |
| Amino acid residues Tyr-67, Asn-72, and Asp-73 of the TVB receptor are important for subgroup E avian sarcoma and leukosis virus interaction. Virology 318:371-80, 2004. Pubmed reference: 14972562. DOI: 10.1016/j.virol.2003.09.024. | |
| 2002 | Chi, Y., Diaz-Griffero, F., Wang, C., Young, J.A., Brojatsch, J. : |
| An NF-kappa B-dependent survival pathway protects against cell death induced by TVB receptors for avian leukosis viruses. J Virol 76:5581-7, 2002. Pubmed reference: 11991986. | |
| Klucking, S., Adkins, H.B., Young, J.A. : | |
| Resistance to infection by subgroups B, D, and E avian sarcoma and leukosis viruses is explained by a premature stop codon within a resistance allele of the tvb receptor gene. J Virol 76:7918-21, 2002. Pubmed reference: 12097608. | |
| Knauss, D.J., Young, J.A. : | |
| A fifteen-amino-acid TVB peptide serves as a minimal soluble receptor for subgroup B avian leukosis and sarcoma viruses. J Virol 76:5404-10, 2002. Pubmed reference: 11991969. | |
| 2001 | Adkins, H.B., Blacklow, S.C., Young, J.A. : |
| Two functionally distinct forms of a retroviral receptor explain the nonreciprocal receptor interference among subgroups B, D, and E avian leukosis viruses. J Virol 75:3520-6, 2001. Pubmed reference: 11264341. DOI: 10.1128/JVI.75.8.3520-3526.2001. | |
| 2000 | Adkins, H.B., Brojatsch, J., Young, J.A. : |
| Identification and characterization of a shared TNFR-related receptor for subgroup B, D, and E avian leukosis viruses reveal cysteine residues required specifically for subgroup E viral entry. J Virol 74:3572-78, 2000. Pubmed reference: 10729132. | |
| Brojatsch, J., Naughton, J., Adkins, H.B., Young, J.A. : | |
| TVB receptors for cytopathic and noncytopathic subgroups of avian leukosis viruses are functional death receptors. J Virol 74:11490-4, 2000. Pubmed reference: 11090145. | |
| 1998 | Smith, E.J., Brojatsch, J., Naughton, J., Young, J.A.T. : |
| The CAR1 gene encoding a cellular receptor specific for subgroup b and d avian leukosis viruses maps to the chicken tvb locus Journal of Virology 72:3501-3503, 1998. Pubmed reference: 9525691. | |
| 1997 | Adkins, H.B., Brojatsch, J., Naughton, J., Rolls, M.M., Pesola, J.M., Young, J.A. : |
| Identification of a cellular receptor for subgroup E avian leukosis virus. Proc Natl Acad Sci U S A 94:11617-22, 1997. Pubmed reference: 9326659. | |
| 1996 | Brojatsch, J., Naughton, J., Rolls, M.M., Zingler, K., Young, J.A.T. : |
| CAR1, a tnfr-related protein, is a cellular receptor for cytopathic avian leukosis sarcoma viruses and mediates apoptosis Cell 87:845-855, 1996. Pubmed reference: 8945512. | |
| 1976 | Pani, P.K. : |
| Further studies in genetic resistance of fowl to RSV(RAV O): evidence for interaction between independently segregating tumour virus b and tumour virus e genes. J Gen Virol 32:441-53, 1976. Pubmed reference: 184240. | |
| 1975 | Crittenden, L.B., Motta, J.V. : |
| The role of the tvb locus in genetic resistance to RSV(RAV-O). Virology 67:327-34, 1975. Pubmed reference: 171832. | |
| 1967 | Crittenden, L.B., Stone, H.A., Reamer, R.H., Okazaki, W. : |
| Two loci controlling genetic cellular resistance to avian leukosis-sarcoma viruses. J Virol 1:898-904, 1967. Pubmed reference: 4316238. |
Edit History
- Created by Frank Nicholas on 12 Sep 2005
- Changed by Frank Nicholas on 01 Sep 2011
- Changed by Frank Nicholas on 10 Oct 2011
- Changed by Frank Nicholas on 09 Dec 2011
- Changed by Frank Nicholas on 18 Feb 2012
- Changed by Frank Nicholas on 21 Sep 2012
- Changed by Frank Nicholas on 21 Aug 2014
- Changed by Frank Nicholas on 15 May 2020
- Changed by Imke Tammen2 on 16 Oct 2023