OMIA:001617-32536 : Sweet taste, lack of in Acinonyx jubatus (cheetah)

In other species: domestic cat , tiger

Categories: Taste / olfaction phene

Links to possible relevant human trait(s) and/or gene(s) in OMIM: 606226 (gene)

Mendelian trait/disorder: yes

Considered a defect: yes

Key variant known: yes

Year key variant first reported: 2005

Cross-species summary: By sequencing very likely candidate genes (i.e. "genes involved in the initial transduction of sweet perception [which] might account for the indifference to sweet-tasting foods by cats"), Li et al. (2005) provided convincing evidence that one of the two genes required for the heteromer T1R2/T1R3 sweet-taste receptor, namely TAS1R2, is a non-functional pseudogene in all cats, tigers and cheetahs: in these species, the TAS1R2 gene has "a 247-base pair microdeletion in exon 3 and stop codons in exons 4 and 6" (Li et al., 2005). The authors argued that it seems likely that this same pseudogene may exist in all felidae.

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
TAS1R2 Acinonyx jubatus C1 NC_069381.1 (13484483..13467075) TAS1R2 Homologene, Ensembl , NCBI gene


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WARNING! Inclusion of a variant in this table does not automatically mean that it should be used for DNA testing. Anyone contemplating the use of any of these variants for DNA testing should examine critically the relevant evidence (especially in breeds other than the breed in which the variant was first described). If it is decided to proceed, the location and orientation of the variant sequence should be checked very carefully.

Since October 2021, OMIA includes a semiautomated lift-over pipeline to facilitate updates of genomic positions to a recent reference genome position. These changes to genomic positions are not always reflected in the ‘acknowledgements’ or ‘verbal description’ fields in this table.

OMIA Variant ID Breed(s) Variant Phenotype Gene Allele Type of Variant Source of Genetic Variant Reference Sequence Chr. g. or m. c. or n. p. Verbal Description EVA ID Year Published PubMed ID(s) Acknowledgements
668 Sweet taste, lack TAS1R2 deletion, gross (>20) Naturally occurring variant "a 247-base pair microdeletion in exon 3 and stop codons in exons 4 and 6" 2005 16103917

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2012). OMIA:001617-32536: Online Mendelian Inheritance in Animals (OMIA) [dataset].


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2006 Li, X., Li, W., Wang, H., Bayley, D.L., Cao, J., Reed, D.R., Bachmanov, A.A., Huang, L., Legrand-Defretin, V., Beauchamp, G.K., Brand, J.G. :
Cats lack a sweet taste receptor. J Nutr 136:1932S-1934S, 2006. Pubmed reference: 16772462.
2005 Li, X., Li, W., Wang, H., Cao, J., Maehashi, K., Huang, L., Bachmanov, A.A., Reed, D.R., Legrand-Defretin, V., Beauchamp, G.K., Brand, J.G. :
Pseudogenization of a sweet-receptor gene accounts for cats' indifference toward sugar. PLoS Genet 1:27-35, 2005. Pubmed reference: 16103917. DOI: 10.1371/journal.pgen.0010003.

Edit History

  • Created by Frank Nicholas on 04 Oct 2011
  • Changed by Frank Nicholas on 12 Oct 2011
  • Changed by Frank Nicholas on 22 Mar 2012