OMIA 001619-9685 : Muscular dystrophy, congenital merosin-deficient in Felis catus |
Possibly relevant human trait(s) and/or gene(s) (MIM number):
607855 (trait)
Mendelian trait/disorder:
yes
Mode of inheritance:
Autosomal
Considered a defect:
yes
Key variant known:
no
Molecular basis:
O'Brien et al. (2001) reported a deficiency of laminin alpha 2 (also called merosin) in affected cats. Presumably this is due to lack of expression of the LAMA2 gene.
Breeds:
Devon Rex,
Maine Coon,
Sphynx.
References
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
| 2008 | Awamura, Y., Uchida, K., Arikawa-Hirasawa, E. : | |
| Long-term follow-up of laminin alpha2 (merosin)-deficient muscular dystrophy in a cat. J Feline Med Surg 10:274-9, 2008. Pubmed reference: 18243745. DOI: 10.1016/j.jfms.2007.11.003. | ||
| 2003 | Poncelet, L., Résibois, A., Engvall, E., Shelton, G.D. : | |
| Laminin alpha2 deficiency-associated muscular dystrophy in a Maine coon cat. J Small Anim Pract 44:550-2, 2003. Pubmed reference: 14692554. | ||
| 2002 | Shelton, G.D., Engvall, E. : | |
| Muscular dystrophies and other inherited myopathies. Vet Clin North Am Small Anim Pract 32:103-24, 2002. Pubmed reference: 11785725. | ||
| 2001 | O'Brien, D.P., Johnson, G.C., Liu, L.A., Guo, L.T., Engvall, E., Powell, H.C., Shelton, G.D. : | |
| Laminin alpha 2 (merosin)-deficient muscular dystrophy and demyelinating neuropathy in two cats. J Neurol Sci 189:37-43, 2001. Pubmed reference: 11535231. |
Edit History
- Created by Frank Nicholas on 07 Oct 2011
- Changed by Frank Nicholas on 07 Oct 2011