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OMIA:001694-9685 : Resistance/susceptibility to lentivirus in Felis catus

In other species: sheep , chimpanzee

Categories: Immune system phene

Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 186940 (gene) , 607750 (gene)

Links to MONDO diseases: No links.

Mendelian trait/disorder: yes

Mode of inheritance: Autosomal dominant

Considered a defect: unknown

Key variant known: yes

Year key variant first reported: 2016

Species-specific name: Resistance/susceptibility to feline immunodeficiency virus (FIV)

Molecular basis: Yoshikawa et al. (2016) "demonstrated that feline A3Z3 hap V is maintained under conditions of positive selection and is resistant to FIV Vif-dependent degradation. . . . To the best of our knowledge, this is the first report providing evidence of the evolutionary arms race between domestic cat and its lentivirus FIV". The likely causal variant for resistance is 65I.

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
APOBEC3C apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C Felis catus B4 NC_058374.1 (132502418..132508873) APOBEC3C Homologene, Ensembl , NCBI gene

Reference

2016 Yoshikawa, R., Izumi, T., Yamada, E., Nakano, Y., Misawa, N., Ren, F., Carpenter, M.A., Ikeda, T., Münk, C., Harris, R.S., Miyazawa, T., Koyanagi, Y., Sato, K. :
A naturally occurring domestic cat APOBEC3 variant confers resistance to feline immunodeficiency virus infection. J Virol 90:474-85, 2016. Pubmed reference: 26491161 . DOI: 10.1128/JVI.02612-15.

Edit History


  • Created by Frank Nicholas on 04 Jun 2016
  • Changed by Frank Nicholas on 04 Jun 2016
  • Changed by Frank Nicholas on 15 May 2020