OMIA:001807-9615 : Leishmaniasis, susceptibility/resistance to in Canis lupus familiaris (dog)

Categories: Immune system phene

Possibly relevant human trait(s) and/or gene(s) (MIM number): 602068 (trait)

Links to MONDO diseases: No links.

Mendelian trait/disorder: unknown

Considered a defect: yes

Mapping: By conducting a GWAS on 115 resistant and 104 susceptible Boxer dogs, each genotyped with the Illumina CanineHD BeadChip (yielding 126,607 SNPs for analysis), Quilez et al. (2012) highlighted regions on chromosomes CFA1, 4, and 20 "although none of these were statistically significant at a genome-wide level and after correcting for genetic stratification and lifestyle".

Genetic engineering: Unknown
Have human generated variants been created, e.g. through genetic engineering and gene editing

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2022). OMIA:001807-9615: Online Mendelian Inheritance in Animals (OMIA) [dataset].


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2023 Álvarez, L., Marín-García, P.J., Llobat, L. :
Genetic haplotypes associated with immune response to Leishmania infantum infection in dogs. Vet Res Commun , 2023. Pubmed reference: 37059873. DOI: 10.1007/s11259-023-10123-z.
2022 Gonçalves-de-Albuquerque, S.D.C., da Silva, L.G., Sousa-Paula, L.C., Sales, K.G.D.S., Boegel, A., Dantas-Torres, F. :
Exploring IL-17 gene promoter polymorphisms in canine leishmaniasis. Acta Trop 232:106452, 2022. Pubmed reference: 35421384. DOI: 10.1016/j.actatropica.2022.106452.
2019 de Vasconcelos, T.C.B., Furtado, M.C., Belo, V.S., Morgado, F.N., Figueiredo, F.B. :
Canine susceptibility to visceral leishmaniasis: A systematic review upon genetic aspects, considering breed factors and immunological concepts. Infect Genet Evol 74:103293, 2019. Pubmed reference: 28987807. DOI: 10.1016/j.meegid.2017.10.005.
2016 Batista, L.F., Utsunomiya, Y.T., da Silva, T.B., Dias, R.A., Tomokane, T.Y., Pacheco, A.D., da Matta, V.L., Silveira, F.T., Marcondes, M., Nunes, C.M., Laurenti, M.D. :
Genome-wide association study for cell-mediated response of dogs naturally infected by Leishmania infantum. Infect Immun , 2016. Pubmed reference: 27736777. DOI: 10.1128/IAI.00486-16.
2015 Utsunomiya, Y.T., Ribeiro, É.S., Quintal, A.P., Sangalli, J.R., Gazola, V.R., Paula, H.B., Trinconi, C.M., Lima, V.M., Perri, S.H., Taylor, J.F., Schnabel, R.D., Sonstegard, T.S., Garcia, J.F., Nunes, C.M. :
Genome-wide scan for visceral leishmaniasis in mixed-breed dogs identifies candidate genes involved in T helper cells and macrophage signaling. PLoS One 10:e0136749, 2015. Pubmed reference: 26348501. DOI: 10.1371/journal.pone.0136749.
2012 Quilez, J., Martínez, V., Woolliams, J.A., Sanchez, A., Pong-Wong, R., Kennedy, L.J., Quinnell, R.J., Ollier, W.E., Roura, X., Ferrer, L., Altet, L., Francino, O. :
Genetic control of canine leishmaniasis: genome-wide association study and genomic selection analysis. PLoS One 7:e35349, 2012. Pubmed reference: 22558142. DOI: 10.1371/journal.pone.0035349.
2007 Jeronimo, S.M., Duggal, P., Ettinger, N.A., Nascimento, E.T., Monteiro, G.R., Cabral, A.P., Pontes, N.N., Lacerda, H.G., Queiroz, P.V., Gomes, C.E., Pearson, R.D., Blackwell, J.M., Beaty, T.H., Wilson, M.E. :
Genetic predisposition to self-curing infection with the protozoan Leishmania chagasi: a genomewide scan. J Infect Dis 196:1261-9, 2007. Pubmed reference: 17955446. DOI: 10.1086/521682.

Edit History

  • Created by Frank Nicholas on 20 May 2013
  • Changed by Frank Nicholas on 20 May 2013
  • Changed by Imke Tammen2 on 10 Sep 2021
  • Changed by Imke Tammen2 on 11 Sep 2022