OMIA:001856-9913 : Tuberculosis, susceptibility/resistance to in Bos taurus (taurine cattle)

In other species: dog , pig , indicine cattle (zebu) , African buffalo , water buffalo

Categories: Immune system phene

Links to possible relevant human trait(s) and/or gene(s) in OMIM: 607949 (trait) , 611046 (trait) , 612929 (trait) , 300259 (trait) , 607948 (trait)

Mendelian trait/disorder: no

Mode of inheritance: Multifactorial

Considered a defect: yes

Key variant known: no

Species-specific description: This phene includes references to studies involving genetically modified organisms (GMO).

Genetic engineering: Yes - in addition to the occurrence of natural variants, variants have been created artificially, e.g. by genetic engineering or gene editing
Have human generated variants been created, e.g. through genetic engineering and gene editing

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:001856-9913: Online Mendelian Inheritance in Animals (OMIA) [dataset].


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2024 Lee, S., Clémentine, C., Kim, H. :
Exploring the genetic factors behind the discrepancy in resistance to bovine tuberculosis between African zebu cattle and European taurine cattle. Sci Rep 14:2370, 2024. Pubmed reference: 38287127. DOI: 10.1038/s41598-024-52606-2.
2023 Banos, G. :
Selective breeding can contribute to bovine tuberculosis control and eradication. Ir Vet J 76:19, 2023. Pubmed reference: 37620894. DOI: 10.1186/s13620-023-00250-z.
Blowey, R. :
A look at bovine TB control over 70 years. Vet Rec 192:380, 2023. Pubmed reference: 37288928. DOI: 10.1002/vetr.3030.
Kumar, R., Gandham, S., Rana, A., Maity, H.K., Sarkar, U., Dey, B. :
Divergent proinflammatory immune responses associated with the differential susceptibility of cattle breeds to tuberculosis. Front Immunol 14:1199092, 2023. Pubmed reference: 37795082. DOI: 10.3389/fimmu.2023.1199092.
Maurić Maljković, M., Vlahek, I., Piplica, A., Ekert Kabalin, A., Sušić, V., Stevanović, V. :
Prospects of toll-like receptors in dairy cattle breeding. Anim Genet 54:425-434, 2023. Pubmed reference: 37051618. DOI: 10.1111/age.13325.
Voller, C., Brouwer, A., Upton, P.A., Waller, E., Duncan, D., Harris, K.A., Marriott, E., Avigad, R. :
Bovine TB infection status in cattle in Great Britain in 2021. Vet Rec 193:e3288, 2023. Pubmed reference: 37477314. DOI: 10.1002/vetr.3288.
2021 Chai, J., Wang, Q., Qin, B., Wang, S., Wang, Y., Shahid, M., Liu, K., Zhang, Y., Qu, W. :
Association of NOS2A gene polymorphisms with susceptibility to bovine tuberculosis in Chinese Holstein cattle. PLoS One 16:e0253339, 2021. Pubmed reference: 34138949. DOI: 10.1371/journal.pone.0253339.
Singh, P., Ali, S.A. :
Impact of CRISPR-Cas9-based genome engineering in farm animals. Vet Sci 8:122, 2021. Pubmed reference: 34209174. DOI: 10.3390/vetsci8070122.
2020 Callaby, R., Kelly, R., Mazeri, S., Egbe, F., Benedictus, L., Clark, E., Doeschl-Wilson, A., Bronsvoort, B., Salavati, M., Muwonge, A. :
Genetic Diversity of Cameroon Cattle and a Putative Genomic Map for Resistance to Bovine Tuberculosis. Front Genet 11:550215, 2020. Pubmed reference: 33281865. DOI: 10.3389/fgene.2020.550215.
Holder, A., Garty, R., Elder, C., Mesnard, P., Laquerbe, C., Bartens, M.C., Salavati, M., Shabbir, M.Z., Tzelos, T., Connelly, T., Villarreal-Ramos, B., Werling, D. :
Analysis of genetic variation in the bovine SLC11A1 gene, its influence on the expression of NRAMP1 and potential association with resistance to bovine tuberculosis. Front Microbiol 11:1420, 2020. Pubmed reference: 32714308. DOI: 10.3389/fmicb.2020.01420.
2019 González-Ruiz, S., Strillacci, M.G., Durán-Aguilar, M., Cantó-Alarcón, G.J., Herrera-Rodríguez, S.E., Bagnato, A., Guzmán, L.F., Milián-Suazo, F., Román-Ponce, S.I. :
Genome-wide association study in Mexican Holstein cattle reveals novel quantitative trait loci regions and confirms mapped loci for resistance to bovine tuberculosis. Animals (Basel) 9, 2019. Pubmed reference: 31480266. DOI: 10.3390/ani9090636.
Ring, S.C., Purfield, D.C., Good, M., Breslin, P., Ryan, E., Blom, A., Evans, R.D., Doherty, M.L., Bradley, D.G., Berry, D.P. :
Variance components for bovine tuberculosis infection and multi-breed genome-wide association analysis using imputed whole genome sequence data. PLoS One 14:e0212067, 2019. Pubmed reference: 30763354. DOI: 10.1371/journal.pone.0212067.
2017 Gao, Y., Wu, H., Wang, Y., Liu, X., Chen, L., Li, Q., Cui, C., Liu, X., Zhang, J., Zhang, Y. :
Single Cas9 nickase induced generation of NRAMP1 knockin cattle with reduced off-target effects. Genome Biol 18:13, 2017. Pubmed reference: 28143571. DOI: 10.1186/s13059-016-1144-4.
Liu, K., Zhang, B., Teng, Z., Wang, Y., Dong, G., Xu, C., Qin, B., Song, C., Chai, J., Li, Y., Shi, X., Shu, X., Zhang, Y. :
Association between SLC11A1 (NRAMP1) polymorphisms and susceptibility to tuberculosis in Chinese Holstein cattle. Tuberculosis (Edinb) 103:10-15, 2017. Pubmed reference: 28237028. DOI: 10.1016/
2016 Broughan, J.M., Judge, J., Ely, E., Delahay, R.J., Wilson, G., Clifton-Hadley, R.S., Goodchild, A.V., Bishop, H., Parry, J.E., Downs, S.H. :
A review of risk factors for bovine tuberculosis infection in cattle in the UK and Ireland. Epidemiol Infect :1-28, 2016. Pubmed reference: 27452974. DOI: 10.1017/S095026881600131X.
2015 Wu, H., Wang, Y., Zhang, Y., Yang, M., Lv, J., Liu, J., Zhang, Y. :
TALE nickase-mediated SP110 knockin endows cattle with increased resistance to tuberculosis. Proc Natl Acad Sci U S A 112:E1530-9, 2015. Pubmed reference: 25733846. DOI: 10.1073/pnas.1421587112.
2014 Bermingham, M.L., Bishop, S.C., Woolliams, J.A., Pong-Wong, R., Allen, A.R., McBride, S.H., Ryder, J.J., Wright, D.M., Skuce, R.A., McDowell, S.W., Glass, E.J. :
Genome-wide association study identifies novel loci associated with resistance to bovine tuberculosis. Heredity (Edinb) , 2014. Pubmed reference: 24496092. DOI: 10.1038/hdy.2013.137.
2013 Amos, W., Brooks-Pollock, E., Blackwell, R., Driscoll, E., Nelson-Flower, M., Conlan, A.J. :
Genetic predisposition to pass the standard SICCT test for bovine tuberculosis in British cattle. PLoS One 8:e58245, 2013. Pubmed reference: 23554880. DOI: 10.1371/journal.pone.0058245.
le Roex, N., van Helden, P.D., Koets, A.P., Hoal, E.G. :
Bovine TB in livestock and wildlife: what's in the genes? Physiol Genomics 45:631-7, 2013. Pubmed reference: 23757394. DOI: 10.1152/physiolgenomics.00061.2013.
2012 Finlay, E.K., Berry, D.P., Wickham, B., Gormley, E.P., Bradley, D.G. :
A genome wide association scan of bovine tuberculosis susceptibility in Holstein-Friesian dairy cattle. PLoS One 7:e30545, 2012. Pubmed reference: 22355315. DOI: 10.1371/journal.pone.0030545.
Müller, A., Möller, M., Adams, L.A., Warren, R.M., Hoal, E.G., van Helden, P.D. :
Comparative analysis of a putative tuberculosis-susceptibility gene, MC3R, and pseudogene sequences in cattle, African buffalo, hyena, rhinoceros and other African bovids and ruminants. Cytogenet Genome Res 136:117-22, 2012. Pubmed reference: 22286663. DOI: 10.1159/000335464.
Sun, L., Song, Y., Riaz, H., Yang, H., Hua, G., Guo, A., Yang, L. :
Polymorphisms in toll-like receptor 1 and 9 genes and their association with tuberculosis susceptibility in Chinese Holstein cattle. Vet Immunol Immunopathol 147:195-201, 2012. Pubmed reference: 22572235. DOI: 10.1016/j.vetimm.2012.04.016.
Vordermeier, M., Ameni, G., Berg, S., Bishop, R., Robertson, B.D., Aseffa, A., Hewinson, R.G., Young, D.B. :
The influence of cattle breed on susceptibility to bovine tuberculosis in Ethiopia. Comp Immunol Microbiol Infect Dis 35:227-32, 2012. Pubmed reference: 22304898. DOI: 10.1016/j.cimid.2012.01.003.
2011 Amos, W., Driscoll, E., Hoffman, J.I. :
Candidate genes versus genome-wide associations: which are better for detecting genetic susceptibility to infectious disease? Proc Biol Sci 278:1183-8, 2011. Pubmed reference: 20926441. DOI: 10.1098/rspb.2010.1920.
Driscoll, E.E., Hoffman, J.I., Green, L.E., Medley, G.F., Amos, W. :
A preliminary study of genetic factors that influence susceptibility to bovine tuberculosis in the British cattle herd. PLoS One 6:e18806, 2011. Pubmed reference: 21533277. DOI: 10.1371/journal.pone.0018806.
Kadarmideen, H.N., Ali, A.A., Thomson, P.C., Müller, B., Zinsstag, J. :
Polymorphisms of the SLC11A1 gene and resistance to bovine tuberculosis in African Zebu cattle. Anim Genet 42:656-8, 2011. Pubmed reference: 22035008. DOI: 10.1111/j.1365-2052.2011.02203.x.
2010 Allen, A.R., Minozzi, G., Glass, E.J., Skuce, R.A., McDowell, S.W., Woolliams, J.A., Bishop, S.C. :
Bovine tuberculosis: the genetic basis of host susceptibility. Proc Biol Sci 277:2737-45, 2010. Pubmed reference: 20519223. DOI: 10.1098/rspb.2010.0830.
Bermingham, M.L., More, S.J., Good, M., Cromie, A.R., Higgins, I.M., Berry, D.P. :
Genetic correlations between measures of Mycobacterium bovis infection and economically important traits in Irish Holstein-Friesian dairy cows. J Dairy Sci 93:5413-22, 2010. Pubmed reference: 20965357. DOI: 10.3168/jds.2009-2925.
Brotherstone, S., White, I.M., Coffey, M., Downs, S.H., Mitchell, A.P., Clifton-Hadley, R.S., More, S.J., Good, M., Woolliams, J.A. :
Evidence of genetic resistance of cattle to infection with Mycobacterium bovis. J Dairy Sci 93:1234-42, 2010. Pubmed reference: 20172243. DOI: 10.3168/jds.2009-2609.
LoBue, P.A., Enarson, D.A., Thoen, C.O. :
Tuberculosis in humans and animals: an overview. Int J Tuberc Lung Dis 14:1075-8, 2010. Pubmed reference: 20819249.
2009 Bermingham, M.L., More, S.J., Good, M., Cromie, A.R., Higgins, I.M., Brotherstone, S., Berry, D.P. :
Genetics of tuberculosis in Irish Holstein-Friesian dairy herds. J Dairy Sci 92:3447-56, 2009. Pubmed reference: 19528623. DOI: 10.3168/jds.2008-1848.
2008 Naranjo, V., Acevedo-Whitehouse, K., Vicente, J., Gortazar, C., de la Fuente, J. :
Influence of methylmalonyl-CoA mutase alleles on resistance to bovine tuberculosis in the European wild boar (Sus scrofa). Anim Genet 39:316-20, 2008. Pubmed reference: 18454807. DOI: 10.1111/j.1365-2052.2008.01725.x.
2007 Morris, C.A. :
A review of genetic resistance to disease in Bos taurus cattle. Vet J 174:481-91, 2007. Pubmed reference: 17095270. DOI: 10.1016/j.tvjl.2006.09.006.
1986 Pugh, G.W., McDonald, T.J., Kopecky, K.E., Kvasnicka, W.G. :
Infectious bovine keratoconjunctivitis: evidence for genetic modulation of resistance in purebred Hereford cattle. Am J Vet Res 47:885-9, 1986. Pubmed reference: 3516033.
1981 Petukhov, V.L. :
[Genetics of cattle resistance to tuberculosis. I. The age of having the disease, milk productivity and the maternal influence on the incidence of the infection in progeny]. Genetika 17:1088-94, 1981. Pubmed reference: 7195860.
1958 Bo, G., Secchi, A. :
[Natural factors in resistance to tuberculosis. 3. Resistance of cattle, horses and dogs to tuberculosis]. G Batteriol Virol Immunol 51:47-53, 1958. Pubmed reference: 13586611.

Edit History

  • Created by Frank Nicholas on 15 Jun 2013
  • Changed by Imke Tammen2 on 03 Dec 2020
  • Changed by Imke Tammen2 on 25 Jun 2021
  • Changed by Imke Tammen2 on 11 Aug 2021
  • Changed by Imke Tammen2 on 28 Aug 2021
  • Changed by Imke Tammen2 on 18 Dec 2023