OMIA:001894-9796 : Cervical vertebral compressive myelopathy in Equus caballus (horse) |
In other species: dog , mountain zebra , sheep
Categories: Skeleton phene (incl. short stature & teeth) , Nervous system phene
Mendelian trait/disorder: unknown
Disease-related: yes
Cross-species summary: Also known as hereditary ataxia
Species-specific name: Cervical vertebral malformation and malarticulation; cervical vertebral stenotic myelopathy; cervical stenotic myelopathy; “wobbler’s” syndrome; wobbler; wobbling; wobbles
Inheritance: From the results of an extensive pedigree analysis of 121 cases in US Thoroughbreds, Dymock (1950) reported that "the evidence suggests the recessive nature of the defect" but was careful to note exceptions to single-locus inheritance. He concluded that "The complete genetic interpretation must await further observation and research." Falco et al. (1976) reported "no evidence of a genetic basis was found" in UK Thoroughbreds.
Cite this entry
Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2013). OMIA:001894-9796: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70
References
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
| 2024 | Dyson, S., Quiney, L., Phillips, K., Zheng, S., Aleman, M. : |
| Radiological abnormalities of the cervicothoracic vertebrae in Warmblood horses with primary neck-related clinical signs versus controls. Vet Radiol Ultrasound , 2024. Pubmed reference: 39161192. DOI: 10.1111/vru.13420. | |
| May-Davis, S., Eckelbarger, P.B., Dzingle, D., Saber, E. : | |
| Characterization and association of the missing ventral tubercle(s) from the sixth cervical vertebra and transpositions on the ventral surface of the seventh cervical vertebra in modern Equus ferus caballus. Animals (Basel) 14:1830, 2024. Pubmed reference: 38929448. DOI: 10.3390/ani14121830. | |
| 2023 | Donnelly, C.G., Johnson, A.L., Reed, S., Finno, C.J. : |
| Cerebrospinal fluid and serum proteomic profiles accurately distinguish neuroaxonal dystrophy from cervical vertebral compressive myelopathy in horses. J Vet Intern Med 37:689-696, 2023. Pubmed reference: 36929645. DOI: 10.1111/jvim.16660. | |
| Mannaa, M., Shamaa, A.A., Shawky, A., Hassan, I.M., Refaey, A.M., Abu-Seida, A.M. : | |
| A novel surgical technique for treatment of cervical vertebral stenotic myelopathy (wobbler syndrome) in a filly. J Equine Vet Sci 126:104493, 2023. Pubmed reference: 37072073. DOI: 10.1016/j.jevs.2023.104493. | |
| 1994 | Tomizawa, N., Nishimura, R., Sasaki, N., Nakayama, H., Kadosawa, T., Senba, H., Takeuchi, A. : |
| Relationships Between Radiography of Cervical Vertebrae and Histopathology of the Cervical Cord in 19 Wobbling Foals J Vet Med Sci 56:227-33, 1994. Pubmed reference: 8075209. DOI: 10.1292/jvms.56.227. | |
| 1989 | Anon. : |
| Success for equine wobbler surgery. Aust Vet J 66:suppl 8, 1989. Pubmed reference: 2930385. | |
| 1980 | Spaul, G., Palmer, A.C., Allsopp, J.D., Hughes-Parry, E.M. : |
| Wobbler syndrome (cervical stenosis) in a Percheron colt. Vet Rec 107:362, 1980. Pubmed reference: 7210440. DOI: 10.1136/vr.107.15.362-a. | |
| 1978 | Kero, T., Kuussaari, J. : |
| Spinal ataxia in the horse. A case report. Nord Vet Med 30:546-51, 1978. Pubmed reference: 733483. | |
| 1976 | Falco, M.J., Whitwell, K., Palmer, A.C. : |
| An investigation into the genetics of 'wobbler disease' in thoroughbred horses in Britain Equine Vet J 8:165-9, 1976. Pubmed reference: 976231. DOI: 10.1111/j.2042-3306.1976.tb03331.x. | |
| 1974 | Montali, R.G., Bush, M., Sauer, R.M., Gray, C.W., Xanten, W.A. : |
| Spinal ataxia in Zebras: comparison with wobbler syndrome in horses Vet Pathol 11:68-78, 1974. Pubmed reference: 4432358. DOI: 10.1177/030098587401100108. | |
| 1972 | Rooney, J.R. : |
| Etiology of the wobbler syndrome. Mod Vet Pract 53:42, 1972. Pubmed reference: 5072971. | |
| 1967 | Fraser, H., Palmer, A.C. : |
| Equine incoordination and wobbler disease of young horses Vet Rec 80:338-55, 1967. Pubmed reference: 6067622. DOI: 10.1136/vr.80.11.338. | |
| 1950 | Dimock, W.W. : |
| "Wobbles" an hereditary disease in horses. J Hered 41:319-23, 1950. Pubmed reference: 14824538. DOI: 10.1093/oxfordjournals.jhered.a106074. |
Edit History
- Created by Carrie Finno on 11 Dec 2013
- Changed by Carrie Finno on 11 Dec 2013