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OMIA:001990-10036 : Cancer, TP53-related in Mesocricetus auratus (golden hamster)

In other species: crab-eating macaque , dog , pig

Categories: Neoplasm

Links to possible relevant human trait(s) and/or gene(s) in OMIM: 109800 (trait) , 114480 (trait) , 137215 (trait) , 601626 (trait) , 211980 (trait) , 260350 (trait) , 614470 (trait) , 202300 (trait) , 114500 (trait) , 114550 (trait) , 607107 (trait) , 259500 (trait) , 614740 (trait) , 137800 (trait) , 191170 (gene) , 190070 (gene) , 151623 (trait)

Mendelian trait/disorder: yes

Disease-related: yes

Key variant known: no

Species-specific description: Miao et al. (2021) describe a cancer phenotype in TP53 knockout golden Syrian hamsters. This phene includes references to studies involving genetically modified organisms (GMO).

Genetic engineering: Yes - variants have been created artificially, e.g. by genetic engineering or gene editing
Have human generated variants been created, e.g. through genetic engineering and gene editing

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
Tp53 tumor protein p53 Mesocricetus auratus NW_024429191.1 (48447627..48459485) Tp53 Homologene, Ensembl , NCBI gene

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2024). OMIA:001990-10036: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70

Reference

2021 Miao, J., Li, R., Wettere, A.J.V., Guo, H., Tabaran, A.F., O'Sullivan, M.G., Carlson, T., Scott, P.M., Chen, K., Gao, D., Li, H., Wang, Y., Wang, Z., Cormier, R.T. :
Cancer spectrum in TP53-deficient golden Syrian hamsters: A new model for Li-Fraumeni syndrome. J Carcinog 20:18, 2021. Pubmed reference: 34729050. DOI: 10.4103/jcar.jcar_18_21.

Edit History


  • Created by Imke Tammen2 on 08 Nov 2021
  • Changed by Imke Tammen2 on 18 Dec 2023
  • Changed by Imke Tammen2 on 18 Oct 2024