OMIA:002073-9915 : Resistance/susceptibility to Mannheimia haemolytica leukotoxin in Bos indicus (indicine cattle (zebu))

In other species: taurine cattle

Categories: Immune system phene

Possibly relevant human trait(s) and/or gene(s) (MIM number): 600065 (gene)

Links to MONDO diseases: No links.

Mendelian trait/disorder: unknown

Considered a defect: yes

Molecular basis: Workman et al. (2018) reported evidence suggesting "that missense variants in the CD18 signal peptide affect Lkt [a M. haemolytica leukotoxin "that binds to the CD18 receptor on leukocytes, initiates lysis, induces inflammation, and causes acute fibrinous bronchopneumonia"] binding, and animals carrying the C 5 allele may be more susceptible to the effects of Lkt."

Genetic engineering: Unknown
Have human generated variants been created, e.g. through genetic engineering and gene editing

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:002073-9915: Online Mendelian Inheritance in Animals (OMIA) [dataset].


2018 Workman, A.M., Chitko-McKown, C.G., Smith, T.P.L., Bennett, G.L., Kalbfleisch, T.S., Basnayake, V., Heaton, M.P. :
A bovine CD18 signal peptide variant with increased binding activity to Mannheimia hemolytica leukotoxin. F1000Res 7:1985, 2018. Pubmed reference: 30881690. DOI: 10.12688/f1000research.17187.1.

Edit History

  • Created by Imke Tammen2 on 08 Oct 2023
  • Changed by Imke Tammen2 on 08 Oct 2023