OMIA 002159-9685 : Coat colour, golden in Felis catus

In other species: tiger

Possibly relevant human trait(s) and/or gene(s) (MIM number): 605236 (gene)

Mendelian trait/disorder: yes

Mode of inheritance: Autosomal Recessive

Considered a defect: no

Key variant known: yes

Year key variant first reported: 2021

Species-specific name: Sunshine

Species-specific symbol: wb^SIB

Inheritance: Beauvois et al. (2021): "Pedigree analyses revealed an autosomal recessive inheritance pattern" for the golden phenotype in Siberian cats.

Abitol et al. (2022): "Order of dominance was established as follow: Wb+ > wbeSIB > wbSIB"

Mapping: Beauvois et al. (2021): "A single candidate region was identified [on chromosome FCA B1] by genome-wide association study (GWAS) and homozygosity mapping. . . . This region contains a strong candidate gene, CORIN (Corin, serine peptidase, chromosome B1: 167 578 182–167 835 768 bp, Felis_catus 9.0) encoding a transmembrane serine protease, known to play a critical role in specifying coat color and acting as a suppressor of the ASIP pathway."

Molecular basis: Beauvois et al. (2021): "A homozygous CORIN:c.2383C>T missense variant was identified in sunshine tabby cats. Segregation of the variant was consistent with recessive inheritance. . . . The CORIN:c.2383C>T variant was predicted to change an arginine to a cysteine at position 795 in the protein: CORIN:p.(Arg795Cys). Finally, hair observation in Siberian cats was consistent with elongated ASIP signaling as golden hair showed a large yellow band instead of the short subapical one usually observed in agouti hair." Beauvois et al. (2021) proposed "that the CORIN:c.2383C>T variant represents the wb^SIB (Siberian recessive wideband) allele in the domestic cat".

Abitol et al. (2022; DOI: 10.1111/age.13215) "identified a second CORIN missense variant associated with the extreme-sunshine modification of Siberian cats. We propose that this CORIN:c.839G>A variant represents the wbeSIB (Siberian recessive extreme wideband) allele in the domestic cat."

Abitol et al. (2022; DOI: 10.1111/age.13228) "identified a third CORIN variant associated with the copper modification of British cats. We propose that this CORIN:c.2425C>T variant represents the wbBSH (British recessive wideband) allele in the domestic cat, which further enlarges the panel of recessive CORIN wideband alleles described in animals."

Prevalence: Beauvois et al. (2021): "The variant was also found in three Kurilian bobtail cats and in two ToyBob cats from the 99 Lives dataset but genotyping of 106 cats from 13 breeds failed to identify carriers in cats from other breeds."

Breed: Siberian.

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
CORIN corin, serine peptidase Felis catus B1 NC_058371.1 (164895076..165152497) CORIN Homologene, Ensembl, NCBI gene

Variants

By default, variants are sorted chronologically by year of publication, to provide a historical perspective. Readers can re-sort on any column by clicking on the column header. Click it again to sort in a descending order. To create a multiple-field sort, hold down Shift while clicking on the second, third etc relevant column headers.

WARNING! Inclusion of a variant in this table does not automatically mean that it should be used for DNA testing. Anyone contemplating the use of any of these variants for DNA testing should examine critically the relevant evidence (especially in breeds other than the breed in which the variant was first described). If it is decided to proceed, the location and orientation of the variant sequence should be checked very carefully.

Since October 2021, OMIA includes a semiautomated lift-over pipeline to facilitate updates of genomic positions to a recent reference genome position. These changes to genomic positions are not always reflected in the ‘acknowledgements’ or ‘verbal description’ fields in this table.

OMIA Variant ID Breed(s) Variant Phenotype Gene Allele Type of Variant Source of Genetic Variant Reference Sequence Chr. g. or m. c. or n. p. Verbal Description EVA ID Inferred EVA rsID Year Published PubMed ID(s) Acknowledgements
1463 British Shorthair Copper (British recessive wideband) CORIN wb^BSH nonsense (stop-gain) Naturally occurring variant Felis_catus_9.0 B1 c.2425C>T p.(R809*) ON640807 2022 35703390
1456 Siberian Extreme sunshine (Siberian recessive extreme wideband) CORIN wb^eSIB missense Naturally occurring variant Felis_catus_9.0 B1 g.167737406G>A c.839G>A p.(C280Y) XM_019829549.2; XP_019685108.1; reported as Genbank ID ON355336 2022 35574714
1313 Siberian Sunshine (golden) CORIN wb^SIB missense Naturally occurring variant Felis_catus_9.0 B1 g.167809720C>T c.2383C>T p.(R795C) XM_019829551.2; XP_019685110.1 2021 33970502 Genomic position in Felis_catus_9.0 provided by Joshua Khamis.

References


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2022 Abitbol, M., Dargar, T., Gache, V. :
Golden cats: The story goes on. Anim Genet :, 2022. Pubmed reference: 35574714. DOI: 10.1111/age.13215.
Abitbol, M., Dargar, T., Gache, V. :
Golden cats: A never-ending story! Anim Genet :, 2022. Pubmed reference: 35703390. DOI: 10.1111/age.13228.
2021 Beauvois, H., Dufaure de Citres, C., Gache, V., Abitbol, M. :
Siberian cats help in solving part of the mystery surrounding golden cats. Anim Genet 52:482-91, 2021. Pubmed reference: 33970502. DOI: 10.1111/age.13076.

Edit History


  • Created by Frank Nicholas on 14 May 2021
  • Changed by Frank Nicholas on 14 May 2021
  • Changed by Frank Nicholas on 18 May 2022
  • Changed by Frank Nicholas on 20 Jun 2022