OMIA:002229-118797 : Hypotrichosis, HR-related in Lipotes vexillifer (Yangtze River dolphin)

In other species: domestic cat , bottlenosed dolphin , beluga whale , minke whale , pig , sheep , Indo-Pacific finless porpoise , long-beaked common dolphin , Omura's baleen whale

Categories: Integument (skin) phene

Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 203655 (trait) , 602302 (gene)

Links to MONDO diseases: No links.

Mendelian trait/disorder: yes

Considered a defect: no

Key variant known: yes

Year key variant first reported: 2013

Cross-species summary: Also known as Hairless

Molecular basis: Chen et al. (2013) reported evidence that the HR gene in cetaceans, including Lipotes vexillifer, has degenerated into a non-functional pseudogene, which is consistent with the hairlessness of this species.

Genetic engineering: Unknown
Have human generated variants been created, e.g. through genetic engineering and gene editing

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
HR hair growth associated Lipotes vexillifer NW_006776652.1 (1434940..1419446) HR Homologene, Ensembl , NCBI gene

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2020). OMIA:002229-118797: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70

Reference

2013 Chen, Z., Wang, Z., Xu, S., Zhou, K., Yang, G. :
Characterization of hairless (Hr) and FGF5 genes provides insights into the molecular basis of hair loss in cetaceans. BMC Evol Biol 13:34, 2013. Pubmed reference: 23394579. DOI: 10.1186/1471-2148-13-34.

Edit History


  • Created by Frank Nicholas on 27 Jan 2020
  • Changed by Frank Nicholas on 27 Jan 2020