OMIA:002291-9615 : Maxillary canine-tooth mesioversion in Canis lupus familiaris (dog)

Categories: Skeleton phene (incl. short stature & teeth)

Mendelian trait/disorder: unknown

Considered a defect: yes

Mapping: Abrams et al. (2020) "conducted independent genomewide association studies in the small Shetland Sheepdog breed and discovered a locus on chromosome 9 that is associated with a dental abnormality called maxillary canine-tooth mesioversion (MCM) (P = 1.53 × 10−7) as well as two body size traits: height (P = 1.67 × 10−5) and weight (P = 1.16 × 10−7)"

Markers: Abrans et al. (2020): "Using whole-genome resequencing data, we identified variants in two proximal genes: FTSJ3, encoding an RNA methyltransferase, and GH1, encoding growth hormone. A substitution in FTSJ3 and a splice donor insertion in GH1 are strongly associated with MCM and reduced body size in Shetland Sheepdogs".

Clinical features: Abrams et al. 92020): "maxillary canine-tooth mesioversion (MCM) describes an upper canine tooth that is displaced forward toward the nose, also known as a lance canine . . . . One or both maxillary canines may be affected. MCM can cause traumatic occlusion, ulceration of the upper lip, and/or periodontal disease and may require extraction or orthodontic repositioning".

Breed: Shetland Sheepdog (Dog) (VBO_0201217).
Breeds in which the phene has been documented. (If a likely causal variant has been documented for the phene, see the variant table breeds in which the variant has been reported).

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2022). OMIA:002291-9615: Online Mendelian Inheritance in Animals (OMIA) [dataset].


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2020 Abrams, S.R., Hawks, A.L., Evans, J.M., Famula, T.R., Mahaffey, M., Johnson, G.S., Mason, J.M., Clark, L.A. :
Variants in FtsJ RNA 2'-O-Methyltransferase 3 and Growth Hormone 1 are associated with small body size and a dental anomaly in dogs. Proc Natl Acad Sci U S A 117:24929-24935, 2020. Pubmed reference: 32958658. DOI: 10.1073/pnas.2009500117.
2008 Legendre, L., Stepaniuk, K. :
Correction of maxillary canine tooth mesioversion in dogs. J Vet Dent 25:216-21, 2008. Pubmed reference: 19025142. DOI: 10.1177/089875640802500312.

Edit History

  • Created by Frank Nicholas on 26 Oct 2020
  • Changed by Frank Nicholas on 26 Oct 2020
  • Changed by Imke Tammen2 on 28 Oct 2022