OMIA:002311-9823 : sterile, male, NANOS2-related in Sus scrofa (pig)

In other species: taurine cattle , goat

Categories: Reproductive system phene

Links to possible relevant human trait(s) and/or gene(s) in OMIM: 608228 (gene)

Mendelian trait/disorder: yes

Considered a defect: yes

Key variant known: no

Species-specific description: Park et al. (2017) "utilized the CRISPR/Cas9 system to edit the NANOS2 gene in pig embryos ... NANOS2 knockout male pigs are expected to serve as an ideal surrogate for transplantation of donor spermatogonial stem cells to expand the availability of gametes from genetically desirable sires." This is a genetically-modified organism (GMO).

Genetic engineering: Yes - variants have been created artificially, e.g. by genetic engineering or gene editing
Have human generated variants been created, e.g. through genetic engineering and gene editing

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
NANOS2 nanos homolog 2 (Drosophila) Sus scrofa 6 NC_010448.4 (52219834..52218889) NANOS2 Homologene, Ensembl , NCBI gene

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:002311-9823: Online Mendelian Inheritance in Animals (OMIA) [dataset].


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2020 Ciccarelli, M., Giassetti, M.I., Miao, D., Oatley, M.J., Robbins, C., Lopez-Biladeau, B., Waqas, M.S., Tibary, A., Whitelaw, B., Lillico, S., Park, C.H., Park, K.E., Telugu, B., Fan, Z., Liu, Y., Regouski, M., Polejaeva, I.A., Oatley, J.M. :
Donor-derived spermatogenesis following stem cell transplantation in sterile NANOS2 knockout males. Proc Natl Acad Sci U S A 117:24195-24204, 2020. Pubmed reference: 32929012. DOI: 10.1073/pnas.2010102117.
2017 Park, K.E., Kaucher, A.V., Powell, A., Waqas, M.S., Sandmaier, S.E., Oatley, M.J., Park, C.H., Tibary, A., Donovan, D.M., Blomberg, L.A., Lillico, S.G., Whitelaw, C.B., Mileham, A., Telugu, B.P., Oatley, J.M. :
Generation of germline ablated male pigs by CRISPR/Cas9 editing of the NANOS2 gene. Sci Rep 7:40176, 2017. Pubmed reference: 28071690. DOI: 10.1038/srep40176.

Edit History

  • Created by Imke Tammen2 on 18 Feb 2021
  • Changed by Imke Tammen2 on 18 Feb 2021
  • Changed by Imke Tammen2 on 18 Dec 2023