OMIA:002335-9615 : Prostate cancer in Canis lupus familiaris (dog)

Categories: Neoplasm

Mendelian trait/disorder: unknown

Mode of inheritance: Multifactorial

Considered a defect: yes

Species-specific description: Teske et al. (2002): "Prostate cancer is one of the most important malignancies in men in the Western world. ... The dog is one of the few other species in which spontaneous prostate cancer occurs." Teske et al. (2002) "investigated the frequency of prostate cancer among prostatic abnormalities in dogs and evaluated whether castration influences the incidence of prostate cancer in dogs. Other factors such as age at castration, age at diagnosis, and breed were included in an attempt to improve insight into the pathogenesis of prostate cancer in the dog .... We observed an increased risk of benign prostatic disease in the Scottish terrier, the Bouvier des Flandres, the Bernese mountain dog and the German Pointer. To our knowledge, a breed specificity for BPH, in Doberman Pinschers, has only been reported once before [Krawiec and Heflin, 1992]."

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2021). OMIA:002335-9615: Online Mendelian Inheritance in Animals (OMIA) [dataset].


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2024 Aeschlimann, L., Kehl, A., Guscetti, F., Posthaus, C., Aupperle-Lellbach, H., Rottenberg, S., de Brot, S. :
Effective detection of BRAF V595E mutation in canine urothelial and prostate carcinomas using immunohistochemistry. Vet Comp Oncol 22:295-302, 2024. Pubmed reference: 38659202. DOI: 10.1111/vco.12978.
Gibson, E.A., Culp, W.T.N. :
Canine prostate cancer: Current treatments and the role of interventional oncology. Vet Sci 11:169, 2024. Pubmed reference: 38668436. DOI: 10.3390/vetsci11040169.
2023 Costagliola, A., Lombardi, R., Liguori, G., Morrione, A., Giordano, A. :
Orexins and prostate cancer: State of the art and potential experimental and therapeutic perspectives. Cancer Genomics Proteomics 20:637-645, 2023. Pubmed reference: 38035703. DOI: 10.21873/cgp.20412.
Oh, J.H., Cho, J.Y. :
Comparative oncology: overcoming human cancer through companion animal studies. Exp Mol Med 55:725-734, 2023. Pubmed reference: 37009802. DOI: 10.1038/s12276-023-00977-3.
Thomsen, M.K., Busk, M. :
Pre-clinical models to study human prostate cancer. Cancers (Basel) 15:4212, 2023. Pubmed reference: 37686488. DOI: 10.3390/cancers15174212.
Vasilatis, D.M., Lucchesi, C.A., Ghosh, P.M. :
Molecular similarities and differences between canine prostate cancer and human prostate cancer variants. Biomedicines 11:1100, 2023. Pubmed reference: 37189720. DOI: 10.3390/biomedicines11041100.
2021 Leis-Filho, A.F., Lainetti, P.F., Franzoni, M.S., Palmieri, C., Kobayshi, P.E., Laufer-Amorim, R., Fonseca-Alves, C.E. :
A comparative in silico analysis of CD24's prognostic value in human and canine prostate cancer. J Pers Med 11:232, 2021. Pubmed reference: 33806857. DOI: 10.3390/jpm11030232.
Ryman-Tubb, T., Lothion-Roy, J.H., Metzler, V.M., Harris, A.E., Robinson, B.D., Rizvanov, A.A., Jeyapalan, J.N., James, V.H., England, G., Rutland, C.S., Persson, J.L., Kenner, L., Rubin, M.A., Mongan, N.P., de Brot, S. :
Comparative pathology of dog and human prostate cancer. Vet Med Sci 8:110-120, 2021. Pubmed reference: 34628719. DOI: 10.1002/vms3.642.
2019 Costa, C.D., Justo, A.A., Kobayashi, P.E., Story, M.M., Palmieri, C., Laufer Amorim, R., Fonseca-Alves, C.E. :
Characterization of OCT3/4, Nestin, NANOG, CD44 and CD24 as stem cell markers in canine prostate cancer. Int J Biochem Cell Biol 108:21-28, 2019. Pubmed reference: 30633985. DOI: 10.1016/j.biocel.2019.01.002.
Palmieri, C., Foster, R.A., Grieco, V., Fonseca-Alves, C.E., Wood, G.A., Culp, W.T.N., Murua Escobar, H., De Marzo, A.M., Laufer-Amorim, R. :
Histopathological Terminology Standards for the Reporting of Prostatic Epithelial Lesions in Dogs. J Comp Pathol 171:30-37, 2019. Pubmed reference: 31540623. DOI: 10.1016/j.jcpa.2019.07.005.
2018 Fonseca-Alves, C.E., Kobayashi, P.E., Rivera Calderón, L.G., Felisbino, S.L., Rinaldi, J.C., Drigo, S.A., Rogatto, S.R., Laufer-Amorim, R. :
Immunohistochemical panel to characterize canine prostate carcinomas according to aberrant p63 expression. PLoS One 13:e0199173, 2018. Pubmed reference: 29894516. DOI: 10.1371/journal.pone.0199173.
2009 Leroy, B.E., Northrup, N. :
Prostate cancer in dogs: comparative and clinical aspects. Vet J 180:149-62, 2009. Pubmed reference: 18786842. DOI: 10.1016/j.tvjl.2008.07.012.
2002 Teske, E., Naan, E.C., van Dijk, E.M., Van Garderen, E., Schalken, J.A. :
Canine prostate carcinoma: epidemiological evidence of an increased risk in castrated dogs. Mol Cell Endocrinol 197:251-5, 2002. Pubmed reference: 12431819. DOI: 10.1016/s0303-7207(02)00261-7.
1992 Krawiec, D.R., Heflin, D. :
Study of prostatic disease in dogs: 177 cases (1981-1986). J Am Vet Med Assoc 200:1119-22, 1992. Pubmed reference: 1376729.

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  • Created by Imke Tammen2 on 21 Apr 2021