In other species: domestic horse , pig , taurine cattle , indicine cattle (zebu) , cheetah

Categories: Reproductive system phene

Single-gene trait/disorder: unknown

Disease-related: yes

Species summary: Su et al. (2024) used CRISPR/Cas9 technology to create homozygous mutants of steroidogenic acute regulatory genes: star1 and star1/ star2. Gene editing of star1 and star1/star2 led to the reduction of serum corticosterone, cortisol and 11-ketotestosterone, which impaired male fertility. This study involves gene edited or genetically modified organisms (GMO).

Genetic engineering: Yes - variants have been created artificially, e.g. by genetic engineering or gene editing
Have human generated variants been created, e.g. through genetic engineering and gene editing