OMIA:002357-9823 : Resistance/susceptibility to transmissible gastroenteritis virus (TGEV) in Sus scrofa (pig)

Categories: Immune system phene

Possibly relevant human trait(s) and/or gene(s) (MIM number): 151530 (gene)

Links to MONDO diseases: No links.

Mendelian trait/disorder: unknown

Considered a defect: yes

Species-specific description: Whitworth et al. (2019): "The biological relevance of amino peptidase N (ANPEP) as a putative receptor for TGEV and PEDV in pigs was evaluated by using CRISPR/Cas9 to edit exon 2 of ANPEP resulting in a premature stop codon. Knockout pigs possessing the null ANPEP phenotype and age matched wild type pigs were challenged with either PEDV or TGEV. Fecal swabs were collected daily from each animal beginning 1 day prior to challenge with PEDV until the termination of the study. The presence of virus nucleic acid was determined by PCR. ANPEP null pigs did not support infection with TGEV, but retained susceptibility to infection with PEDV." (GMO)

Genetic engineering: Yes - variants have been created artificially, e.g. by genetic engineering or gene editing
Have human generated variants been created, e.g. through genetic engineering and gene editing

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
ANPEP alanyl (membrane) aminopeptidase Sus scrofa 7 NC_010449.5 (55373856..55351081) ANPEP Homologene, Ensembl , NCBI gene

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:002357-9823: Online Mendelian Inheritance in Animals (OMIA) [dataset].


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2022 Tu, C.F., Chuang, C.K., Yang, T.S. :
The application of new breeding technology based on gene editing in pig industry - A review. Anim Biosci 35:791-803, 2022. Pubmed reference: 34991204. DOI: 10.5713/ab.21.0390.
2020 Stoian, A., Rowland, R.R.R., Petrovan, V., Sheahan, M., Samuel, M.S., Whitworth, K.M., Wells, K.D., Zhang, J., Beaton, B., Cigan, M., Prather, R.S. :
The use of cells from ANPEP knockout pigs to evaluate the role of aminopeptidase N (APN) as a receptor for porcine deltacoronavirus (PDCoV). Virology 541:136-140, 2020. Pubmed reference: 32056711. DOI: 10.1016/j.virol.2019.12.007.
Xu, K., Zhou, Y., Mu, Y., Liu, Z., Hou, S., Xiong, Y., Fang, L., Ge, C., Wei, Y., Zhang, X., Xu, C., Che, J., Fan, Z., Xiang, G., Guo, J., Shang, H., Li, H., Xiao, S., Li, J., Li, K. :
CD163 and pAPN double-knockout pigs are resistant to PRRSV and TGEV and exhibit decreased susceptibility to PDCoV while maintaining normal production performance. Elife 9:e57132, 2020. Pubmed reference: 32876563. DOI: 10.7554/eLife.57132.
2019 Luo, L., Wang, S., Zhu, L., Fan, B., Liu, T., Wang, L., Zhao, P., Dang, Y., Sun, P., Chen, J., Zhang, Y., Chang, X., Yu, Z., Wang, H., Guo, R., Li, B., Zhang, K. :
Aminopeptidase N-null neonatal piglets are protected from transmissible gastroenteritis virus but not porcine epidemic diarrhea virus. Sci Rep 9:13186, 2019. Pubmed reference: 31515498. DOI: 10.1038/s41598-019-49838-y.
Whitworth, K.M., Rowland, R.R.R., Petrovan, V., Sheahan, M., Cino-Ozuna, A.G., Fang, Y., Hesse, R., Mileham, A., Samuel, M.S., Wells, K.D., Prather, R.S. :
Resistance to coronavirus infection in amino peptidase N-deficient pigs. Transgenic Res 28:21-32, 2019. Pubmed reference: 30315482. DOI: 10.1007/s11248-018-0100-3.

Edit History

  • Created by Imke Tammen2 on 25 Jun 2021
  • Changed by Imke Tammen2 on 25 Jun 2021
  • Changed by Imke Tammen2 on 18 Dec 2023