OMIA:002362-9925 : Fecundity, GDF9-related in Capra hircus (goat) |
Categories: Reproductive system phene
Links to possible relevant human trait(s) and/or gene(s) in OMIM: 601918 (gene) , 618014 (trait)
Single-gene trait/disorder: yes
Mode of inheritance: Autosomal
Disease-related: no
Key variant known: yes
Year key variant first reported: 2016
Genetic engineering:
Yes - in addition to the occurrence of natural variants, variants have been created artificially, e.g. by genetic engineering or gene editing
Have human generated variants been created, e.g. through genetic engineering and gene editing
Breeds:
Bengal (Goat) (VBO_0000731),
Shanbei White Cashmere, China (Goat) (VBO_0009450).
Breeds in which the phene or likely causal variants have been documented. If a likely causal variant has been documented, see variant-specific breed information in the variant table. (Breed information may be incomplete).
Associated gene:
| Symbol | Description | Species | Chr | Location | OMIA gene details page | Other Links |
|---|---|---|---|---|---|---|
| GDF9 | growth differentiation factor 9 | Capra hircus | 7 | NC_030814.1 (66023938..66028657) | GDF9 | Ensembl, NCBI gene |
Contact us
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Cite this entry
Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2025). OMIA:002362-9925: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70
References
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
| 2025 | Faris, A.S., Rodrigues, K.F., Zeshan, B., Sarker, S., Candyrine, S.C.L., Rahman, M.M., Kalam, M.A., Bhuiyan, M.S.A. : |
| Polymorphism analysis of GDF9 and BMP15 genes and their association with litter size in crossbreed goats in Malaysia. Trop Anim Health Prod 57:195, 2025. Pubmed reference: 40299199. DOI: 10.1007/s11250-025-04460-1. | |
| Hajian, M., Pirali, A., Moghaddam, S.H.H., Moradi-Hajidavaloo, R., Varnosfaderani, S.R., Jozi, M., Izadi, T., Tanhaie-Vash, N., Kues, W., Nasr-Esfahani, M.H., Jafarpour, F., Eghbalsaied, S. : | |
| Efficient gene editing of BMP15, GDF9, and MSTN-but not the imprinted CLPG gene-in goat embryos via electrotransfection and handmade cloning. Funct Integr Genomics 25:150, 2025. Pubmed reference: 40637794. DOI: 10.1007/s10142-025-01644-8. | |
| 2024 | Montgomery, G.W. : |
| Genetic regulation of ovulation rate and multiple births. Reprod Fertil Dev 36:RD24083, 2024. Pubmed reference: 39222471. DOI: 10.1071/RD24083. | |
| 2023 | Song, T., Liu, Y., Cuomu, R., Tan, Y., A Wang, C., De, J., Cao, X., Zeng, X. : |
| Polymorphisms analysis of BMP15, GDF9 and BMPR1B in Tibetan Cashmere Goat (Capra hircus). Genes (Basel) 14:1102, 2023. Pubmed reference: 37239462. DOI: 10.3390/genes14051102. | |
| 2021 | Aboelhassan, D.M., Darwish, A.M., Ali, N.I., Ghaly, I.S., Farag, I.M. : |
| A study on mutation points of GDF9 gene and their association with prolificacy in Egyptian small ruminants. J Genet Eng Biotechnol 19:85, 2021. Pubmed reference: 34097165. DOI: 10.1186/s43141-021-00181-8. | |
| Das, A., Shaha, M., Gupta, M.D., Dutta, A., Miazi, O.F. : | |
| Polymorphism of fecundity genes (BMP15 and GDF9) and their association with litter size in Bangladeshi prolific Black Bengal goat. Trop Anim Health Prod 53:230, 2021. Pubmed reference: 33772358. DOI: 10.1007/s11250-021-02679-2. | |
| 2020 | Bi, Y., Li, J., Wang, X., He, L., Lan, K., Qu, L., Lan, X., Song, X., Pan, C. : |
| Two novel rare strongly linked missense SNPs (P27R and A85G) within the GDF9 gene were significantly associated with litter size in Shaanbei White Cashmere (SBWC) goats. Front Vet Sci 7:406, 2020. Pubmed reference: 32851004. DOI: 10.3389/fvets.2020.00406. | |
| 2019 | Ghoreishi, H., Fathi-Yosefabad, S., Shayegh, J., Barzegari, A. : |
| Identification of mutations in BMP15 and GDF9 genes associated with prolificacy of Markhoz goats. Arch Anim Breed 62:565-570, 2019. Pubmed reference: 31807668. DOI: 10.5194/aab-62-565-2019. | |
| 2018 | Wang, X., Yang, Q., Wang, K., Yan, H., Pan, C., Chen, H., Liu, J., Zhu, H., Qu, L., Lan, X. : |
| Two strongly linked single nucleotide polymorphisms (Q320P and V397I) in GDF9 gene are associated with litter size in cashmere goats. Theriogenology 125:115-121, 2018. Pubmed reference: 30414564. DOI: 10.1016/j.theriogenology.2018.10.013. | |
| 2016 | Zhao, J., Liu, S., Zhou, X., Zhang, R., Li, Y., Wang, X., Chen, Y. : |
| A non-synonymous mutation in GDF9 is highly associated with litter size in cashmere goats. Anim Genet 47:630-1, 2016. Pubmed reference: 27298140. DOI: 10.1111/age.12447. | |
| 2013 | Pramod, R.K., Sharma, S.K., Singhi, A., Pan, S., Mitra, A. : |
| Differential ovarian morphometry and follicular expression of BMP15, GDF9 and BMPR1B influence the prolificacy in goat. Reprod Domest Anim 48:803-9, 2013. Pubmed reference: 23581245. DOI: 10.1111/rda.12165. |
Edit History
- Created by Imke Tammen2 on 25 Jun 2021
- Changed by Imke Tammen2 on 25 Jun 2021
- Changed by Imke Tammen2 on 21 May 2022
- Changed by Imke Tammen2 on 12 Jul 2025