OMIA:002440-9031 : Resistance/susceptibility to Marek disease virus in Gallus gallus (chicken) |
Categories: Immune system phene
Single-gene trait/disorder: no
Mode of inheritance: Multifactorial
Disease-related: yes
Key variant known: no
Contact us
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Cite this entry
Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2024). OMIA:002440-9031: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70
References
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
| 2025 | Fulton, J.E., Arango, J., Wolc, A. : |
| Effect of MHC Haplotype on Mortality Due to Marek's Disease in Commercial Laying Hens. Animals (Basel) 15:1647, 2025. Pubmed reference: 40509113. DOI: 10.3390/ani15111647. | |
| Kaiser, M., Kaufman, J., Lamont, S.J. : | |
| Different MHC class I cell surface expression levels in diverse chicken lines, associations with B blood group, and proposed relationship to antigen-binding repertoire. Poult Sci 104:104569, 2025. Pubmed reference: 39642749. DOI: 10.1016/j.psj.2024.104569. | |
| Velez-Irizarry, D., Cheng, H., Hearn, C. : | |
| scRNA seq of an F1 cross of Marek's disease resistant and susceptible chickens identifies allele specific expression signatures enriched in transcription modulators. Sci Rep 15:3689, 2025. Pubmed reference: 39880866. DOI: 10.1038/s41598-025-86174-w. | |
| 2024 | Lipkin, E., Smith, J., Soller, M., Burt, D.W., Fulton, J.E. : |
| Mapping quantitative trait loci regions associated with Marek's disease on chicken autosomes by means of selective DNA pooling. Sci Rep 14:31896, 2024. Pubmed reference: 39738313. DOI: 10.1038/s41598-024-83356-w. | |
| 2023 | Han, L., Wu, S., Zhang, T., Peng, W., Zhao, M., Yue, C., Wen, W., Cai, W., Li, M., Wallny, H.J., Avila, D.W., Mwangi, W., Nair, V., Ternette, N., Guo, Y., Zhao, Y., Chai, Y., Qi, J., Liang, H., Gao, G.F., Kaufman, J., Liu, W.J. : |
| A Wider and Deeper Peptide-Binding Groove for the Class I Molecules from B15 Compared with B19 Chickens Correlates with Relative Resistance to Marek's Disease. J Immunol 210:668-680, 2023. Pubmed reference: 36695776. DOI: 10.4049/jimmunol.2200211. | |
| He, Y., Taylor, R.L., Bai, H., Ashwell, C.M., Zhao, K., Li, Y., Sun, G., Zhang, H., Song, J. : | |
| Transgenerational epigenetic inheritance and immunity in chickens that vary in Marek's disease resistance. Poult Sci 102:103036, 2023. Pubmed reference: 37832188. DOI: 10.1016/j.psj.2023.103036. | |
| Hearn, C.J., Cheng, H.H. : | |
| Contribution of the TCRβ repertoire to Marek's disease genetic resistance in the chicken. Viruses 15:607, 2023. Pubmed reference: 36992316. DOI: 10.3390/v15030607. | |
| 2022 | Bertzbach, L.D., Tregaskes, C.A., Martin, R.J., Deumer, U.S., Huynh, L., Kheimar, A.M., Conradie, A.M., Trimpert, J., Kaufman, J., Kaufer, B.B. : |
| The diverse major histocompatibility complex haplotypes of a common commercial chicken line and their effect on Marek's disease virus pathogenesis and tumorigenesis. Front Immunol 13:908305, 2022. Pubmed reference: 35693787. DOI: 10.3389/fimmu.2022.908305. | |
| 2021 | Boodhoo, N., Behboudi, S. : |
| Differential Virus-Specific IFN-Gamma Producing T Cell Responses to Marek's Disease Virus in Chickens With B19 and B21 MHC Haplotypes. Front Immunol 12:784359, 2021. Pubmed reference: 35095857. DOI: 10.3389/fimmu.2021.784359. | |
| Halabi, S., Ghosh, M., Stevanović, S., Rammensee, H.G., Bertzbach, L.D., Kaufer, B.B., Moncrieffe, M.C., Kaspers, B., Härtle, S., Kaufman, J. : | |
| The dominantly expressed class II molecule from a resistant MHC haplotype presents only a few Marek's disease virus peptides by using an unprecedented binding motif. PLoS Biol 19:e3001057, 2021. Pubmed reference: 33901176. DOI: 10.1371/journal.pbio.3001057. | |
| Jin, Y.C., Wang, W., Yu, M.M., Hao, M.L., Zeng, G., Chen, J.F., Dai, J., Wu, Y.J. : | |
| Study on the contrast of the MHC-peptide interaction of B2/B21 haplotype and MHC-related virus resistance in chickens. Immun Inflamm Dis 9:1670-1677, 2021. Pubmed reference: 34473901. DOI: 10.1002/iid3.520. | |
| 2020 | Smith, J., Lipkin, E., Soller, M., Fulton, J.E., Burt, D.W. : |
| Mapping QTL associated with resistance to avian oncogenic Marek's disease virus (MDV) reveals major candidate genes and variants. Genes (Basel) 11:1019, 2020. Pubmed reference: 32872585. DOI: 10.3390/genes11091019. | |
| 2018 | Kim, T., Hunt, H.D., Parcells, M.S., van Santen, V., Ewald, S.J. : |
| Two class I genes of the chicken MHC have different functions: BF1 is recognized by NK cells while BF2 is recognized by CTLs. Immunogenetics 70:599-611, 2018. Pubmed reference: 29947944. DOI: 10.1007/s00251-018-1066-2. | |
| Xu, L., He, Y., Ding, Y., Liu, G.E., Zhang, H., Cheng, H.H., Taylor, R.L., Song, J. : | |
| Genetic assessment of inbred chicken lines indicates genomic signatures of resistance to Marek's disease. J Anim Sci Biotechnol 9:65, 2018. Pubmed reference: 30221000. DOI: 10.1186/s40104-018-0281-x. | |
| 2016 | Perumbakkam, S., Hunt, H.D., Cheng, H.H. : |
| Differences in CD8αα and cecal microbiome community during proliferation and late cytolytic phases of Marek's disease virus infection are associated with genetic resistance to Marek's disease. FEMS Microbiol Ecol 92, 2016. Pubmed reference: 27604255. DOI: 10.1093/femsec/fiw188. | |
| 2015 | Gao, C., Han, L., Han, J., Liu, J., Jiang, Q., Guo, D., Qu, L. : |
| Establishment of six homozygous MHC-B haplotype populations associated with susceptibility to Marek's disease in Chinese specific pathogen-free BWEL chickens. Infect Genet Evol 29:S1567-1348(14)00402-X:15-25, 2015. Pubmed reference: 25445653. DOI: 10.1016/j.meegid.2014.10.031. | |
| Gennart, I., Coupeau, D., Pejaković, S., Laurent, S., Rasschaert, D., Muylkens, B. : | |
| Marek's disease: Genetic regulation of gallid herpesvirus 2 infection and latency. Vet J 205:S1090-0233(15)00180-X:339-48, 2015. Pubmed reference: 26067852. DOI: 10.1016/j.tvjl.2015.04.038. | |
| Jin, Y.C., Wei, P., Cui, S., Huang, L. : | |
| The Relationship Between the Three-Dimensional (3D) Structures of BF Molecules and MHC-Related Marek's Disease Resistance in Chickens. Scand J Immunol 81:325-7, 2015. Pubmed reference: 25684023. DOI: 10.1111/sji.12278. | |
| Yan, Y., Yang, N., Cheng, H.H., Song, J., Qu, L. : | |
| Genome-wide identification of copy number variations between two chicken lines that differ in genetic resistance to Marek's disease. BMC Genomics 16:843, 2015. Pubmed reference: 26492869. DOI: 10.1186/s12864-015-2080-5. | |
| 2014 | Jin, Y.C., Huang, L., Wei, X.X., Zhao, Z.Y., Li, Y., Wei, P. : |
| The relationship between the alternative exon 7 splice variant of the BF gene and MHC-related Marek's disease resistance in chickens. Scand J Immunol 80:323-6, 2014. Pubmed reference: 25124506. DOI: 10.1111/sji.12216. | |
| Wang, Y., Qiu, M., Yang, J., Zhao, X., Wang, Y., Zhu, Q., Liu, Y. : | |
| Sequence variations of the MHC class I gene exon 2 and exon 3 between infected and uninfected chickens challenged with Marek's disease virus. Infect Genet Evol 21:S1567-1348(13)00392-4:103-9, 2014. Pubmed reference: 24200589. DOI: 10.1016/j.meegid.2013.10.020. | |
| 2013 | Hunt, H.D., Dunn, J.R. : |
| The influence of host genetics on Marek's disease virus evolution. Avian Dis 57:474-82, 2013. Pubmed reference: 23901764. DOI: 10.1637/10315-080212-Reg.1. | |
| Sun, B., Li, X., Wang, Z., Xia, C. : | |
| Complex assembly, crystallization and preliminary X-ray crystallographic analysis of the chicken MHC class I molecule BF2*1501. Acta Crystallogr Sect F Struct Biol Cryst Commun 69:122-5, 2013. Pubmed reference: 23385750. DOI: 10.1107/S1744309112050300. | |
| Yu, C., Liu, Q., Qin, A., Hu, X., Xu, W., Qian, K., Shao, H., Jin, W. : | |
| Expression kinetics of chicken β2-microglobulin and Class I MHC in vitro and in vivo during Marek's disease viral infections. Vet Res Commun 37:277-83, 2013. Pubmed reference: 23918553. DOI: 10.1007/s11259-013-9572-z. | |
| 2012 | Zhang, J., Chen, Y., Qi, J., Gao, F., Liu, Y., Liu, J., Zhou, X., Kaufman, J., Xia, C., Gao, G.F. : |
| Narrow groove and restricted anchors of MHC class I molecule BF2*0401 plus peptide transporter restriction can explain disease susceptibility of B4 chickens. J Immunol 189:4478-87, 2012. Pubmed reference: 23041567. DOI: 10.4049/jimmunol.1200885. | |
| 2010 | Jarosinski, K.W., Hunt, H.D., Osterrieder, N. : |
| Down-regulation of MHC class I by the Marek's disease virus (MDV) UL49.5 gene product mildly affects virulence in a haplotype-specific fashion. Virology 405:457-63, 2010. Pubmed reference: 20637486. DOI: 10.1016/j.virol.2010.06.041. | |
| Jin, Y.C., Wei, P., Wei, X.X., Zhao, Z.Y., Li, Y. : | |
| Marek's disease resistant/susceptible MHC haplotypes in Xiayan chickens identified on the basis of BLB2 PCR-RFLP and BLB2/BF2 sequence analyses. Br Poult Sci 51:530-9, 2010. Pubmed reference: 20924848. DOI: 10.1080/00071668.2010.508489. | |
| Lian, L., Qu, L.J., Zheng, J.X., Liu, C.J., Zhang, Y.P., Chen, Y.M., Xu, G.Y., Yang, N. : | |
| Expression profiles of genes within a subregion of chicken major histocompatibility complex B in spleen after Marek's disease virus infection. Poult Sci 89:2123-9, 2010. Pubmed reference: 20852103. DOI: 10.3382/ps.2010-00919. | |
| Thanthrige-Don, N., Read, L.R., Abdul-Careem, M.F., Mohammadi, H., Mallick, A.I., Sharif, S. : | |
| Marek's disease virus influences the expression of genes associated with IFN-gamma-inducible MHC class II expression. Viral Immunol 23:227-32, 2010. Pubmed reference: 20374003. DOI: 10.1089/vim.2009.0092. | |
| 2009 | Dalgaard, T., Boving, M.K., Handberg, K., Jensen, K.H., Norup, L.R., Juul-Madsen, H.R. : |
| MHC expression on spleen lymphocyte subsets in genetically resistant and susceptible chickens infected with Marek's disease virus. Viral Immunol 22:321-7, 2009. Pubmed reference: 19811089. DOI: 10.1089/vim.2009.0033. | |
| Heifetz, E.M., Fulton, J.E., O'Sullivan, N.P., Arthur, J.A., Cheng, H., Wang, J., Soller, M., Dekkers, J. : | |
| Mapping QTL affecting resistance to Marek's disease in an F6 advanced intercross population of commercial layer chickens. BMC Genomics 10:20, 2009. Pubmed reference: 19144166. DOI: 10.1186/1471-2164-10-20. | |
| 2008 | Sarson, A.J., Parvizi, P., Lepp, D., Quinton, M., Sharif, S. : |
| Transcriptional analysis of host responses to Marek's disease virus infection in genetically resistant and susceptible chickens. Anim Genet 39:232-40, 2008. Pubmed reference: 18371127. DOI: 10.1111/j.1365-2052.2008.01710.x. | |
| Sherman, M.A., Goto, R.M., Moore, R.E., Hunt, H.D., Lee, T.D., Miller, M.M. : | |
| Mass spectral data for 64 eluted peptides and structural modeling define peptide binding preferences for class I alleles in two chicken MHC-B haplotypes associated with opposite responses to Marek's disease. Immunogenetics 60:527-41, 2008. Pubmed reference: 18612635. DOI: 10.1007/s00251-008-0302-6. | |
| 2007 | Shiina, T., Briles, W.E., Goto, R.M., Hosomichi, K., Yanagiya, K., Shimizu, S., Inoko, H., Miller, M.M. : |
| Extended gene map reveals tripartite motif, C-type lectin, and Ig superfamily type genes within a subregion of the chicken MHC-B affecting infectious disease. J Immunol 178:7162-72, 2007. Pubmed reference: 17513765. DOI: 10.4049/jimmunol.178.11.7162. | |
| 2005 | Dalgaard, T.S., Vitved, L., Skjødt, K., Thomsen, B., Labouriau, R., Jensen, K.H., Juul-Madsen, H.R. : |
| Molecular characterization of major histocompatibility complex class I (B-F) mRNA variants from chickens differing in resistance to Marek's disease. Scand J Immunol 62:259-70, 2005. Pubmed reference: 16179013. DOI: 10.1111/j.1365-3083.2005.01652.x. | |
| Haeri, M., Read, L.R., Wilkie, B.N., Sharif, S. : | |
| Identification of peptides associated with chicken major histocompatibility complex class II molecules of B21 and B19 haplotypes. Immunogenetics 56:854-9, 2005. Pubmed reference: 15650875. DOI: 10.1007/s00251-004-0760-4. | |
| 2003 | Dalgaard, T.S., Højsgaard, S., Skjødt, K., Juul-Madsen, H.R. : |
| Differences in chicken major histocompatibility complex (MHC) class Ialpha gene expression between Marek's disease-resistant and -susceptible MHC haplotypes. Scand J Immunol 57:135-43, 2003. Pubmed reference: 12588659. DOI: 10.1046/j.1365-3083.2003.01207.x. | |
| 2002 | Jarosinski, K.W., Yunis, R., O'Connell, P.H., Markowski-Grimsrud, C.J., Schat, K.A. : |
| Influence of genetic resistance of the chicken and virulence of Marek's disease virus (MDV) on nitric oxide responses after MDV infection. Avian Dis 46:636-49, 2002. Pubmed reference: 12243528. DOI: 10.1637/0005-2086(2002)046[0636:IOGROT]2.0.CO;2. | |
| Zekarias, B., Ter Huurne, A.A., Landman, W.J., Rebel, J.M., Pol, J.M., Gruys, E. : | |
| Immunological basis of differences in disease resistance in the chicken. Vet Res 33:109-25, 2002. Pubmed reference: 11944802. DOI: 10.1051/vetres:2002001. | |
| 2001 | Weigend, S., Matthes, S., Sölkner, J., Lamont, S.J. : |
| Resistance to Marek's disease virus in White Leghorn chickens: effects of avian leukosis virus infection genotype, reciprocal mating, and major histocompatibility complex. Poult Sci 80:1064-72, 2001. Pubmed reference: 11495456. DOI: 10.1093/ps/80.8.1064. | |
| 2000 | Bacon, L.D., Hunt, H.D., Cheng, H.H. : |
| A review of the development of chicken lines to resolve genes determining resistance to diseases. Poult Sci 79:1082-93, 2000. Pubmed reference: 10947175. DOI: 10.1093/ps/79.8.1082. | |
| Kaufman, J. : | |
| The simple chicken major histocompatibility complex: life and death in the face of pathogens and vaccines. Philos Trans R Soc Lond B Biol Sci 355:1077-84, 2000. Pubmed reference: 11186309. DOI: 10.1098/rstb.2000.0645. | |
| 1999 | Kaufman, J., Milne, S., Göbel, T.W., Walker, B.A., Jacob, J.P., Auffray, C., Zoorob, R., Beck, S. : |
| The chicken B locus is a minimal essential major histocompatibility complex. Nature 401:923-5, 1999. Pubmed reference: 10553909. DOI: 10.1038/44856. | |
| 1998 | Lakshmanan, N., Lamont, S.J. : |
| Rfp-Y region polymorphism and Marek's disease resistance in multitrait immunocompetence-selected chicken lines. Poult Sci 77:538-41, 1998. Pubmed reference: 9565235. DOI: 10.1093/ps/77.4.538. | |
| Pharr, G.T., Dodgson, J.B., Hunt, H.D., Bacon, L.D. : | |
| Class II MHC cDNAs in 15I5 B-congenic chickens. Immunogenetics 47:350-4, 1998. Pubmed reference: 9510552. DOI: 10.1007/s002510050369. | |
| 1997 | Kaufman, J., Salomonsen, J. : |
| The "minimal essential MHC" revisited: both peptide-binding and cell surface expression level of MHC molecules are polymorphisms selected by pathogens in chickens. Hereditas 127:67-73, 1997. Pubmed reference: 9420472. DOI: 10.1111/j.1601-5223.1997.t01-1-00067.x. | |
| Lakshmanan, N., Gavora, J.S., Lamont, S.J. : | |
| Major histocompatibility complex class II DNA polymorphisms in chicken strains selected for Marek's disease resistance and egg production or for egg production alone. Poult Sci 76:1517-23, 1997. Pubmed reference: 9355145. DOI: 10.1093/ps/76.11.1517. | |
| Pharr, G.T., Vallejo, R.L., Bacon, L.D. : | |
| Identification of Rfp-Y (Mhc-like) haplotypes in chickens of Cornell lines N and P. J Hered 88:504-12, 1997. Pubmed reference: 9419890. DOI: 10.1093/oxfordjournals.jhered.a023145. | |
| 1996 | Kaufman, J., Wallny, H.J. : |
| Chicken MHC molecules, disease resistance and the evolutionary origin of birds. Curr Top Microbiol Immunol 212:129-41, 1996. Pubmed reference: 8934816. DOI: 10.1007/978-3-642-80057-3_12. | |
| 1995 | Bacon, L.D., Witter, R.L. : |
| Efficacy of Marek's disease vaccines in Mhc heterozygous chickens: Mhc congenic x inbred line F1 matings. J Hered 86:269-73, 1995. Pubmed reference: 7657994. DOI: 10.1093/oxfordjournals.jhered.a111580. | |
| 1994 | Schat, K.A., Taylor, R.L., Briles, W.E. : |
| Resistance to Marek's disease in chickens with recombinant haplotypes to the major histocompatibility (B) complex. Poult Sci 73:502-8, 1994. Pubmed reference: 8202429. DOI: 10.3382/ps.0730502. | |
| 1993 | Pinard, M.H., Janss, L.L., Maatman, R., Noordhuizen, J.P., van der Zijpp, A.J. : |
| Effect of divergent selection for immune responsiveness and of major histocompatibility complex on resistance to Marek's disease in chickens. Poult Sci 72:391-402, 1993. Pubmed reference: 8385327. DOI: 10.3382/ps.0720391. | |
| 1989 | Hartmann, W. : |
| Evaluation of "major genes" affecting disease resistance in poultry in respect to their potential for commercial breeding. Prog Clin Biol Res 307:221-31, 1989. Pubmed reference: 2798473. | |
| Martin, A., Dunnington, E.A., Briles, W.E., Briles, R.W., Siegel, P.B. : | |
| Marek's disease and major histocompatibility complex haplotypes in chickens selected for high or low antibody response. Anim Genet 20:407-14, 1989. Pubmed reference: 2619107. DOI: 10.1111/j.1365-2052.1989.tb00896.x. | |
| 1987 | Steadham, E.M., Lamont, S.J., Kujdych, I., Nordskog, A.W. : |
| Association of Marek's disease with Ea-B and immune response genes in subline and F2 populations of the Iowa State S1 Leghorn line. Poult Sci 66:571-5, 1987. Pubmed reference: 3112755. DOI: 10.3382/ps.0660571. | |
| 1984 | Plachý, J., Jurajda, V., Benda, V. : |
| Resistance to Marek's disease is controlled by a gene within the B-F region of the chicken major histocompatibility complex in Rous sarcoma regressor or progressor inbred lines of chickens. Folia Biol (Praha) 30:251-8, 1984. Pubmed reference: 6090234. | |
| 1982 | Briles, W.E., Briles, R.W., Polock, D.L. : |
| Marek's disease resistance of B (MHC) heterozygotes in a cross of purebred leghorn lines Poult Sci 61:205-11, 1982. Pubmed reference: 7088788. DOI: 10.3382/ps.0610205. | |
| 1978 | Longenecker, B.M., Gallatin, W.M. : |
| Genetic control of resistance to Marek's disease. IARC Sci Publ (1971) :845-50, 1978. Pubmed reference: 109390. | |
| 1977 | Nordskog, A.W., Pevzner, I.Y., Trowbridge, C.L., Benedict, A.A. : |
| Immune response and adult mortality associated with the B locus in chickens. Adv Exp Med Biol 88:245-56, 1977. Pubmed reference: 200123. DOI: 10.1007/978-1-4613-4169-7_23. |
Edit History
- Created by Imke Tammen2 on 27 Sep 2021
- Changed by Imke Tammen2 on 24 Sep 2024