OMIA:002448-8030 : Resistance/susceptibility to infectious pancreatic necrosis virus (IPNV) in Salmo salar
Categories: Immune system phene
Possibly relevant human trait(s) and/or gene(s) (MIM number): 603385 (gene)
Links to MONDO diseases: No links.
Mendelian trait/disorder: no
Mode of inheritance: Multifactorial
Considered a defect: unknown
Key variant known: no
Species-specific description: Pavelin et al. (2021): "Whole genome sequencing and functional annotation were used to characterise the major IPNV resistance QTL in Atlantic salmon. Gene expression analyses pointed to NEDD-8 activating enzyme 1 (nae1) as a putative functional candidate underlying the QTL. CRISPR-Cas9 knockout and chemical inhibition of nae1 in cell lines resulted in significant reduction in IPNV replication."
Mapping: Pavelin et al. (2021): "A major quantitative trait locus (QTL) affecting resistance was described by two independent groups [Houston et al., 2008; Moen et al., 2009], and explains 80–100% of the genetic variance in mortality due to the disease."
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
|2021||Pavelin, J., Jin, Y.H., Gratacap, R.L., Taggart, J.B., Hamilton, A., Verner-Jeffreys, D.W., Paley, R.K., Rubin, C.J., Bishop, S.C., Bron, J.E., Robledo, D., Houston, R.D. :|
|The nedd-8 activating enzyme gene underlies genetic resistance to infectious pancreatic necrosis virus in Atlantic salmon. Genomics 113:3842-3850, 2021. Pubmed reference: 34547402 . DOI: 10.1016/j.ygeno.2021.09.012.|
|2015||Moen, T., Torgersen, J., Santi, N., Davidson, W.S., Baranski, M., Ødegård, J., Kjøglum, S., Velle, B., Kent, M., Lubieniecki, K.P., Isdal, E., Lien, S. :|
|Epithelial Cadherin Determines Resistance to Infectious Pancreatic Necrosis Virus in Atlantic Salmon. Genetics 200:1313-26, 2015. Pubmed reference: 26041276 . DOI: 10.1534/genetics.115.175406.|
|2010||Gheyas, A.A., Houston, R.D., Mota-Velasco, J.C., Guy, D.R., Tinch, A.E., Haley, C.S., Woolliams, J.A. :|
|Segregation of infectious pancreatic necrosis resistance QTL in the early life cycle of Atlantic Salmon (Salmo salar). Anim Genet 41:531-6, 2010. Pubmed reference: 20331597 . DOI: 10.1111/j.1365-2052.2010.02032.x.|
|Houston, R.D., Haley, C.S., Hamilton, A., Guy, D.R., Mota-Velasco, J.C., Gheyas, A.A., Tinch, A.E., Taggart, J.B., Bron, J.E., Starkey, W.G., McAndrew, B.J., Verner-Jeffreys, D.W., Paley, R.K., Rimmer, G.S., Tew, I.J., Bishop, S.C. :|
|The susceptibility of Atlantic salmon fry to freshwater infectious pancreatic necrosis is largely explained by a major QTL. Heredity (Edinb) 105:318-27, 2010. Pubmed reference: 19935825 . DOI: 10.1038/hdy.2009.171.|
|2009||Moen, T., Baranski, M., Sonesson, A.K., Kjøglum, S. :|
|Confirmation and fine-mapping of a major QTL for resistance to infectious pancreatic necrosis in Atlantic salmon (Salmo salar): population-level associations between markers and trait. BMC Genomics 10:368, 2009. Pubmed reference: 19664221 . DOI: 10.1186/1471-2164-10-368.|
|2008||Houston, R.D., Haley, C.S., Hamilton, A., Guy, D.R., Tinch, A.E., Taggart, J.B., McAndrew, B.J., Bishop, S.C. :|
|Major quantitative trait loci affect resistance to infectious pancreatic necrosis in Atlantic salmon (Salmo salar). Genetics 178:1109-15, 2008. Pubmed reference: 18245341 . DOI: 10.1534/genetics.107.082974.|
- Created by Imke Tammen2 on 03 Oct 2021
- Changed by Imke Tammen2 on 03 Oct 2021