OMIA 002526-9685 : Enteropathy-associated T cell lymphoma, inducer of in Felis catus
IT IS IMPORTANT TO NOTE THAT THIS IS UNDERSTOOD TO BE A SOMATIC MUTATION, WHICH MEANS THAT THE VARIANT IS NOT INHERITED AND WILL NOT BE PASSED ON TO OFFSPRING.Associated gene:
|Symbol||Description||Species||Chr||Location||OMIA gene details page||Other Links|
|STAT5B||signal transducer and activator of transcription 5B||Felis catus||E1||NC_058381.1 (40929732..40858676)||STAT5B||Homologene, Ensembl, NCBI gene|
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WARNING! Inclusion of a variant in this table does not automatically mean that it should be used for DNA testing. Anyone contemplating the use of any of these variants for DNA testing should examine critically the relevant evidence (especially in breeds other than the breed in which the variant was first described). If it is decided to proceed, the location and orientation of the variant sequence should be checked very carefully.
Since October 2021, OMIA includes a semiautomated lift-over pipeline to facilitate updates of genomic positions to a recent reference genome position. These changes to genomic positions are not always reflected in the ‘acknowledgements’ or ‘verbal description’ fields in this table.
|OMIA Variant ID||Breed(s)||Variant Phenotype||Gene||Allele||Type of Variant||Source of Genetic Variant||Reference Sequence||Chr.||g. or m.||c. or n.||p.||Verbal Description||EVA ID||Inferred EVA rsID||Year Published||PubMed ID(s)||Acknowledgements|
|1425||Alimentary lymphoma, inducer of||STAT5B||missense||Naturally occurring variant||Felis_catus_9.0||E1||g.42844462T>G||c.1924A>C||p.(N642H)||XP_023100377.1; XM_023244609.1; SOMATIC MUTATION||2021||34680385|
|2021||Kieslinger, M., Swoboda, A., Kramer, N., Freund, P., Pratscher, B., Neubauer, H.A., Steinborn, R., Wolfesberger, B., Fuchs-Baumgartinger, A., Moriggl, R., Burgener, I.A. :|
|A recurrent STAT5B^N642H driver mutation in feline alimentary T cell lymphoma. Cancers (Basel) 13:, 2021. Pubmed reference: 34680385. DOI: 10.3390/cancers13205238.|
- Created by Imke Tammen2 on 03 Feb 2022