OMIA:002539-9615 : Respiratory distress syndrome, ANLN-related in Canis lupus familiaris (dog)

Categories: Respiratory system phene

Links to possible relevant human trait(s) and/or gene(s) in OMIM: 616027 (gene)

Mendelian trait/disorder: yes

Mode of inheritance: Autosomal recessive

Considered a defect: yes

Key variant known: yes

Year key variant first reported: 2017

Species-specific name: Also known as Acute respiratory distress syndrome (ARDS)

Inheritance: Eleven affected dogs were from 4 litters, all having a common ancestor. Segregation analysis suggested autosomal recessive inheritance. (Jarvinen et al., 2009)

Molecular basis: Holopainen et al. (2017) "combined SNP-based homozygosity mapping of two ARDS-affected Dalmatian dogs and whole genome sequencing of one affected dog to identify a case-specific homozygous nonsense variant, c.31C>T; p.R11* in the ANLN gene. Subsequent analysis of the variant in a total cohort of 188 Dalmatians, including seven cases, indicated complete segregation of the variant with the disease and confirmed an autosomal recessive mode of inheritance".

Clinical features: Tachypnea and noisy respiration. Shortly before death: respiratory distress, characterized by strenuous and rapid respirations, together with cyanosis and vomiting.

Breed: Dalmatian (Dog) (VBO_0200427).
Breeds in which the phene has been documented. (If a likely causal variant has been documented for the phene, see the variant table breeds in which the variant has been reported).

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
ANLN anillin actin binding protein Canis lupus familiaris 14 NC_051818.1 (47746501..47796142) ANLN Homologene, Ensembl , NCBI gene


By default, variants are sorted chronologically by year of publication, to provide a historical perspective. Readers can re-sort on any column by clicking on the column header. Click it again to sort in a descending order. To create a multiple-field sort, hold down Shift while clicking on the second, third etc relevant column headers.

WARNING! Inclusion of a variant in this table does not automatically mean that it should be used for DNA testing. Anyone contemplating the use of any of these variants for DNA testing should examine critically the relevant evidence (especially in breeds other than the breed in which the variant was first described). If it is decided to proceed, the location and orientation of the variant sequence should be checked very carefully.

Since October 2021, OMIA includes a semiautomated lift-over pipeline to facilitate updates of genomic positions to a recent reference genome position. These changes to genomic positions are not always reflected in the ‘acknowledgements’ or ‘verbal description’ fields in this table.

OMIA Variant ID Breed(s) Variant Phenotype Gene Allele Type of Variant Source of Genetic Variant Reference Sequence Chr. g. or m. c. or n. p. Verbal Description EVA ID Year Published PubMed ID(s) Acknowledgements
353 Dalmatian (Dog) Respiratory distress syndrome ANLN nonsense (stop-gain) Naturally occurring variant CanFam3.1 14 g.47812143C>T c.31C>T p.(R11*) 2017 28222102 Variant coordinates obtained from or confirmed by EBI's Some Effect Predictor (VEP) tool

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2022). OMIA:002539-9615: Online Mendelian Inheritance in Animals (OMIA) [dataset].


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2017 Holopainen, S., Hytönen, M.K., Syrjä, P., Arumilli, M., Järvinen, A.K., Rajamäki, M., Lohi, H. :
ANLN truncation causes a familial fatal acute respiratory distress syndrome in Dalmatian dogs. PLoS Genet 13:e1006625, 2017. Pubmed reference: 28222102. DOI: 10.1371/journal.pgen.1006625.
2009 Syrjä, P., Saari, S., Rajamäki, M., Saario, E., Järvinen, A.K. :
Pulmonary histopathology in Dalmatians with familial acute respiratory distress syndrome (ARDS). J Comp Pathol 141:254-9, 2009. Pubmed reference: 19628215. DOI: 10.1016/j.jcpa.2009.05.008.
1995 Jarvinen, A.K., Saario, E., Andresen, E., Happonen, I., Saari, S., Rajamaki, M. :
Lung injury leading to respiratory distress syndrome in young Dalmatian dogs Journal of Veterinary Internal Medicine 9:162-168, 1995. Pubmed reference: 7674217.

Edit History

  • Created by Imke Tammen2 on 19 Mar 2022
  • Changed by Imke Tammen2 on 19 Mar 2022