OMIA:002563-9940 : Melatonin-enriched in Ovis aries (sheep)

Categories: Endocrine / exocrine gland phene (incl mammary gland)

Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 600950 (gene) , 300015 (gene)

Links to MONDO diseases: No links.

Mendelian trait/disorder: yes

Considered a defect: no

Key variant known: yes

Year key variant first reported: 2017

Species-specific description: Ma et al. (2017) used the CRISPR/Cas9 system to produce thirty-four transgenic sheep which can produce melatonin-enriched milk through the integration of exogenous AANAT and/or ASMT genes into their mammary epithelial cells. Seven sheep carried transgenic AANAT, two carried ASMT, and 25 carried both of AANAT and ASMT genes. “In transgenic offspring, the upregulated gene expressions of AANAT and ASMT rendered the elevated melatonin production in milk.” This phene has been created using genetically modified organisms (GMO). (Entry created by Hannah Edgell, 28/08/2022)

Genetic engineering: Yes - variants have been created artificially, e.g. by genetic engineering or gene editing
Have human generated variants been created, e.g. through genetic engineering and gene editing

Associated genes:

Symbol Description Species Chr Location OMIA gene details page Other Links
AANAT aralkylamine N-acetyltransferase Ovis aries 11 NC_056064.1 (54630556..54628621) AANAT Homologene, Ensembl , NCBI gene
ASMT acetylserotonin O-methyltransferase Ovis aries X NC_056080.1 (6509510..6484197) ASMT Homologene, Ensembl , NCBI gene
ASMT acetylserotonin O-methyltransferase Ovis aries Y NC_082741.1 (892332..918274) ASMT Homologene, Ensembl , NCBI gene

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:002563-9940: Online Mendelian Inheritance in Animals (OMIA) [dataset].


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2023 Wu, H., Ma, W., Yan, L., Liu, F., Xu, S., Ji, P., Gao, S., Zhang, L., Liu, G. :
Investigation of SNP markers for the melatonin production trait in the Hu sheep with bulked segregant analysis. BMC Genomics 24:502, 2023. Pubmed reference: 37648999. DOI: 10.1186/s12864-023-09494-z.
2018 Tian, X., Lv, D., Ma, T., Deng, S., Yang, M., Song, Y., Zhang, X., Zhang, J., Fu, J., Lian, Z., Zhu, S., Wu, Y., Xing, Y., Liu, G. :
AANAT transgenic sheep generated via OPS vitrified-microinjected pronuclear embryos and reproduction efficiency of the transgenic offspring. PeerJ 6:e5420, 2018. Pubmed reference: 30123717. DOI: 10.7717/peerj.5420.
2017 Ma, T., Tao, J., Yang, M., He, C., Tian, X., Zhang, X., Zhang, J., Deng, S., Feng, J., Zhang, Z., Wang, J., Ji, P., Song, Y., He, P., Han, H., Fu, J., Lian, Z., Liu, G. :
An AANAT/ASMT transgenic animal model constructed with CRISPR/Cas9 system serving as the mammary gland bioreactor to produce melatonin-enriched milk in sheep. J Pineal Res 63, 2017. Pubmed reference: 28273380. DOI: 10.1111/jpi.12406.

Edit History

  • Created by Imke Tammen2 on 24 Aug 2022
  • Changed by Imke Tammen2 on 24 Aug 2022
  • Changed by Imke Tammen2 on 25 Aug 2022
  • Changed by Imke Tammen2 on 01 Sep 2023
  • Changed by Imke Tammen2 on 15 Oct 2023
  • Changed by Imke Tammen2 on 18 Dec 2023