OMIA:002601-9940 : Type I interferon receptor deficiency in Ovis aries

Categories: Immune system phene

Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 602376 (gene) , 616669 (trait)

Links to MONDO diseases: No links.

Mendelian trait/disorder: yes

Considered a defect: unknown

Key variant known: yes

Year key variant first reported: 2022

Species-specific description: Davies et al. (2022): "One or both chains of the sheep IFNAR were disrupted in fetal fibroblast lines using CRISPR/Cas9 and 12 lambs were produced by somatic cell nuclear transfer (SCNT). ... Although many lambs have died from SCNT related problems or infections, one fertile IFNAR2 -/- ram lived to over 4 years of age, remained healthy, and produced more than 80 offspring. Interestingly, ZIKV infection studies failed to demonstrate a high level of susceptibility. Presumably, these sheep compensated for a lack of type I IFN signaling using the type II, IFN-gamma and type III, IFN-lambda pathways. ... A breeding herd of 32 IFNAR2 +/- ewes, which are fertile, has been developed for production of IFNAR2 -/- sheep for both infection and reproduction studies." This study involves genetically modified organisms (GMO).

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
IFNAR2 interferon (alpha, beta and omega) receptor 2 Ovis aries 1 NC_056054.1 (123014718..122979204) IFNAR2 Homologene, Ensembl , NCBI gene


2022 Davies, C.J., Fan, Z., Morgado, K.P., Liu, Y., Regouski, M., Meng, Q., Thomas, A.J., Yun, S.I., Song, B.H., Frank, J.C., Perisse, I.V., Van Wettere, A., Lee, Y.M., Polejaeva, I.A. :
Development and characterization of type I interferon receptor knockout sheep: A model for viral immunology and reproductive signaling. Front Genet 13:986316, 2022. Pubmed reference: 36246651 . DOI: 10.3389/fgene.2022.986316.

Edit History

  • Created by Imke Tammen2 on 24 Nov 2022
  • Changed by Imke Tammen2 on 24 Nov 2022