OMIA:002619-9823 : Hypogonadotropic hypogonadism, KISS1-related in Sus scrofa (pig) |
Categories: Reproductive system phene
Links to possible relevant human trait(s) and/or gene(s) in OMIM: 603286 (gene) , 614842 (trait)
Links to relevant human diseases in MONDO:
Mendelian trait/disorder: yes
Disease-related: yes
Key variant known: yes
Year key variant first reported: 2023
Species-specific description: Flórez et al. (2023) generated KISS1-edited pigs using CRISPR/Cas9 genome editing as an alternative to the need to surgically castrate pigs to avoid puberty-derived boar taint and aggressiveness: ".... four KISS1-edited pigs (two boars and two gilts) with disruptive allele frequencies of 96% and 100% demonstrated full hypogonadotropism, infantile reproductive tracts, and failed to reach sexual maturity." This phene includes references to studies involving gene edited or genetically modified organisms (GMO).
Genetic engineering:
Yes - variants have been created artificially, e.g. by genetic engineering or gene editing
Have human generated variants been created, e.g. through genetic engineering and gene editing
Breeds:
Duroc (Pig) (VBO_0001127),
Yorkshire (Pig) (VBO_0001212).
Breeds in which the phene has been documented. (If a likely causal variant has been documented for the phene, see the variant table breeds in which the variant has been reported).
Associated gene:
Symbol | Description | Species | Chr | Location | OMIA gene details page | Other Links |
---|---|---|---|---|---|---|
KISS1 | KiSS-1 metastasis-suppressor | Sus scrofa | 9 | NC_010451.4 (64841071..64834822) | KISS1 | Homologene, Ensembl , NCBI gene |
Cite this entry
Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:002619-9823: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70
Reference
2022 | Flórez, J.M., Martins, K., Solin, S., Bostrom, J.R., Rodríguez-Villamil, P., Ongaratto, F., Larson, S.A., Ganbaatar, U., Coutts, A.W., Kern, D., Murphy, T.W., Kim, E.S., Carlson, D.F., Huisman, A., Sonstegard, T.S., Lents, C.A. : |
CRISPR/Cas9-editing of KISS1 to generate pigs with hypogonadotropic hypogonadism as a castration free trait. Front Genet 13:1078991, 2022. Pubmed reference: 36685939. DOI: 10.3389/fgene.2022.1078991. |
Edit History
- Created by Imke Tammen2 on 01 Feb 2023
- Changed by Imke Tammen2 on 18 Dec 2023