OMIA:002628-8030 : Skin colour, albinism, oculocutaneous type IV in Salmo salar (Atlantic salmon) |
In other species: northern snakehead , redhead cichlid , royal farlowella
Categories: Pigmentation phene
Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 606574 (trait) , 606202 (gene)
Links to MONDO diseases: No links.
Mendelian trait/disorder: yes
Considered a defect: unknown
Key variant known: yes
Year key variant first reported: 2023
Species-specific description: Raudstein et al. (2023) microinjected salmon embryos with LbCas12a ribonucleoprotein complexes targeting the pigmentation gene solute carrier family 45 member 2 (slc45a2). Using CRISPR/LbCas12a, [the authors] were able to knock-out slc45a2 and knock-in a FLAG sequence element by providing single-stranded DNA templates." This study involves genetically modified organisms (GMO).
Genetic engineering:
Yes - variants have been created artificially, e.g. by genetic engineering or gene editing
Have human generated variants been created, e.g. through genetic engineering and gene editing
Associated gene:
| Symbol | Description | Species | Chr | Location | OMIA gene details page | Other Links |
|---|---|---|---|---|---|---|
| slc45a2 | solute carrier family 45, member 2 | Salmo salar | ssa01 | NC_059442.1 (131423988..131398604) | slc45a2 | Homologene, Ensembl , NCBI gene |
Cite this entry
Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:002628-8030: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70
Reference
| 2023 | Raudstein, M., Kjærner-Semb, E., Barvik, M., Broll, S., Straume, A.H., Edvardsen, R.B. : |
| In vivo CRISPR/LbCas12a-mediated knock-in and knock-out in Atlantic salmon (Salmo salar L.). Transgenic Res , 2023. Pubmed reference: 37733197. DOI: 10.1007/s11248-023-00368-4. |
Edit History
- Created by Imke Tammen2 on 23 Sep 2023
- Changed by Imke Tammen2 on 18 Dec 2023