Categories: Immune system phene

Links to MONDO diseases: No links.

Mendelian trait/disorder: no

Mode of inheritance: Multifactorial

Considered a defect: yes

Key variant known: no

Cross-species summary: Viral nervous necrosis (VNN), also called viral encephalopathy and retinopathy (VER), is caused by the betanodavirus nervous necrosis virus (NNV).

Inheritance: Delpuech et al. (2023): "European sea bass exhibits genetic variation in resistance to VNN with a heritability ranging from 0.26 to 0.43 ... "

Mapping: Delpuech et al. (2023) "generated a dataset of 838,451 single nucleotide polymorphisms (SNPs) identified from whole-genome sequencing (WGS) in the parental generation of two commercial populations (A: 2371 individuals and B: 3428 individuals) of European sea bass with phenotypic records for binary survival in a VNN challenge. For each population, three cohorts were submitted to a red-spotted grouper nervous necrosis virus (RGNNV) challenge by immersion and genotyped on a 57K SNP chip. ... [The authors] found several QTL regions that were specific to one of the populations on different linkage groups (LG), and one 127-kb QTL region on LG12 that was shared by both populations and included the genes ZDHHC14, which encodes a palmitoyltransferase, and IFI6/IFI27-like, which encodes an interferon-alpha induced protein."

Genetic engineering: Unknown
Have human generated variants been created, e.g. through genetic engineering and gene editing