In other species: taurine cattle

Categories: Immune system phene

Links to possible relevant human trait(s) and/or gene(s) in OMIM: 120920 (gene)

Single-gene trait/disorder: unknown

Disease-related: yes

Species summary: Workman et al. (2023) "used CRISPR-mediated homology-directed repair and somatic cell nuclear transfer to produce a live calf with a six amino acid substitution in the BVDV binding domain of bovine CD46. The result was a gene-edited calf with dramatically reduced susceptibility to infection as measured by reduced clinical signs and the lack of viral infection in white blood cells. The edited [Gir] calf has no off-target edits and appears normal and healthy at 20 months of age without obvious adverse effects from the on-target edit." This study involves genetically modified organisms (GMO).

Genetic engineering: Yes - variants have been created artificially, e.g. by genetic engineering or gene editing
Have human generated variants been created, e.g. through genetic engineering and gene editing

Breed: Gir (Cattle) (VBO_0000215).
Breeds in which the phene or likely causal variants have been documented. If a likely causal variant has been documented, see variant-specific breed information in the variant table. (Breed information may be incomplete).

Associated gene: